PMID: 9179430May 1, 1997Paper

Fluticasone propionate nasal spray is more effective and has a faster onset of action than placebo in treatment of rhinitis medicamentosa

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
H HallénP Graf

Abstract

Controversy still exists about the treatment of rhinitis medicamentosa and treatment has never been objectively evaluated. To study the effect of fluticasone propionate aqueous nasal spray compared to placebo nasal spray in the treatment of rhinitis medicamentosa. A parallel randomized, double-blind study was conducted to evaluate the treatment of rhinitis medicamentosa. Two groups containing 10 patients with rhinitis medicamentosa in each group stopped their overuse of nasal vasoconstrictor spray immediately and were treated with either fluticasone propionate nasal spray once daily 200 micrograms, or placebo nasal spray for 14 days. The nasal mucosal swelling was recorded with rhinostereometry, acoustic rhinometry and a peak inspiratory flow meter. Nasal stuffiness was estimated on a visual analogue scale in the morning and in the evening of each day. The mucosal swelling decreased after 7 and 14 days of treatment with fluticasone propionate as well as placebo, but the reduction was significantly greater after treatment with fluticasone propionate. The symptom scores for nasal stuffiness showed a marked reduction during the treatment period in both groups, but there was a faster onset of symptom reduction after treatment with ...Continue Reading

Associated Clinical Trials

Citations

Sep 23, 2014·European Journal of Pharmacology·Recep DokuyucuZafer Yonden
Jul 16, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alicja GrzankaJerzy Jarząb
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Eva K Ellegård
Apr 5, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Abdullah TasAhmet R Karasalihoglu

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