Fluvastatin increases heterotopically induced ossicles in mice

Clinical and Experimental Pharmacology & Physiology
R GalusK H Wlodarski

Abstract

1. The aim of the present study was to evaluate the influence of fluvastatin (3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitor) on heterotopic ossification (HO) induced by HeLa cells. 2. C57Bl/6 mice were injected with 3 x 10(6) HeLa cells into right thigh muscles. Mice in the experimental group received fluvastatin 1.2 mg/kg per day for 17 consecutive days, while mice in the control group received placebo. Intact mice served as an additional control. Seventeen days post-HeLa cell grafting, blood samples were collected to measure total serum cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol and alkaline phosphatase (AP). 3. In all animals injected with HeLa cells, the mass of mineral deposited in the induced ossicle was established after hydrolysis of soft tissues surrounding the induced ossicles. In fluvastatin-treated mice, the mass of mineral deposited in heterotopically induced ossicles was significantly increased, when compared to mice receiving placebo. This was followed by a significant decrease of TG concentration; whereas the levels of serum AP were not significantly affected. 4. These results indicate that administration of statins may affect heterotopic ossification. This may also have...Continue Reading

References

Jan 1, 1989·The Journal of Arthroplasty·P Kjaersgaard-AndersenO Sneppen
Oct 1, 1969·Experimental Cell Research·K Wlodarski
Mar 9, 2000·The Journal of Arthroplasty·J W SperlingC M Rowland
Jan 15, 2002·Experimental Biology and Medicine·Iwona Ewa KochanowskaKazimierz Ostrowski
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Andrei C Sposito, M John Chapman
Dec 31, 2004·International Journal of Clinical Pharmacology and Therapeutics·A O MückD Wallwiener
Mar 4, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Christos Hatzigeorgiou, Jeffrey L Jackson
May 27, 2005·The New England Journal of Medicine·Jenny N PoynterGad Rennert

❮ Previous
Next ❯

Citations

Feb 19, 2010·Folia Histochemica Et Cytobiologica·Ryszard GalusJarosław Jóźwiak
Jul 13, 2013·International Journal of Molecular Sciences·Ryszard GalusJarosław Jóźwiak
Sep 18, 2007·Burns : Journal of the International Society for Burn Injuries·David M ShaferKevin N Foster
Nov 6, 2009·Journal of Oral Rehabilitation·Y AyukawaK Koyano
May 12, 2012·Gene Expression Patterns : GEP·Melissa S McNultyRajiv Kumar
Sep 2, 2011·American Journal of Veterinary Research·Matthew D WinterDean H Riedesel

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.