PMID: 6172005Jul 1, 1981Paper

Fluvoxamine and clomipramine in depressed patients. A double-blind clinical study

Acta Psychiatrica Scandinavica
C J KlokD Doogan

Abstract

In a double-blind study we compared fluvoxamine, a new selective serotonin re-uptake inhibitor, with clomipramine. In 36 female inpatients with vital depression, the antidepressant properties of fluvoxamine and clomipramine were studied. Eight patients did not complete the study. During a 4-week treatment period the Hamilton-, Zung-, Clinical Global Impression- and Leyden ratings showed, apart from the last scale in the fluvoxamine group, significant improvement in both groups. In the latter scale, a statistically significant difference was found in favour of clomipramine. Additional anxiolytic-sedative medication was required equally in both groups. CSF data in 10 patients are discussed. Non-specific electrocardiographic (ECG) repolarization disturbances were observed in both groups. Anticholinergic side effects were more prominent with clomipramine than with fluvoxamine; gastrointestinal symptoms and agitation were more prominent with fluvoxamine than with clomipramine. Fluvoxamine did not show particular advantages or disadvantages over clomipramine.

References

Aug 1, 1977·British Journal of Pharmacology·V ClaassenP Placheta
Jan 1, 1965·Archives of General Psychiatry·W W ZUNG
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

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Citations

Jan 1, 1987·Biological Psychiatry·H M van PraagR Kahn
Apr 1, 1993·Journal of Psychiatric Research·M R JohnsonJ C Ballenger
Mar 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S KasperH J Möller
Jan 1, 1989·Psychological Medicine. Monograph Supplement·S J WarringtonM Lader
Jan 1, 1985·Current Medical Research and Opinion·U A SiddiquiD K Jesinger
Jan 1, 1989·Psychosomatics·N J Berwish, J D Amsterdam
Dec 1, 1982·British Journal of Clinical Pharmacology·J F Robinson, D P Doogan
Jun 15, 2013·Journal of Affective Disorders·Viola Oertel-KnöchelDavid E J Linden
Jan 7, 2015·The Journal of Toxicological Sciences·Yukiko Yamazaki-HashimotoAtsushi Sugiyama
Dec 4, 2012·International Journal of Environmental Research and Public Health·Su-Ying Tsai
Jul 20, 2007·The Cochrane Database of Systematic Reviews·J R GeddesJ Boynton
Feb 18, 2005·International Journal of Geriatric Psychiatry·Maria Stella T GironBengt Winblad
Feb 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·M HotopfG Lewis
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Ichiro M OmoriToshi A Furukawa
Jun 1, 1996·Journal of Clinical Psychopharmacology·O Spigset, R Ohman
Oct 3, 1999·Journal of Clinical Psychopharmacology·S L RasmussenP Tanghøj
Aug 26, 1998·Therapeutic Drug Monitoring·S HärtterC Hiemke
Feb 9, 2002·Acta Psychiatrica Scandinavica. Supplementum·L Livianos-Aldana, L Rojo-Moreno
Jan 1, 1983·British Journal of Clinical Pharmacology·J E De WildeJ S Wakelin
Mar 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·J G EdwardsG L Pearce
Mar 28, 1998·British Journal of Clinical Pharmacology·O SpigsetR Dahlqvist

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