PMID: 8968304Nov 1, 1996Paper
Fluvoxamine attenuates panic induced by 35% CO2 challenge
The Journal of Clinical Psychiatry
H PolsE J Griez
Abstract
The authors investigated whether 6 weeks of treatment with fluvoxamine would decrease the anxiogenic response to the 35% CO2 challenge in 11 patients with DSM-III-R panic disorder with agoraphobia. The patients underwent a 35% CO2 challenge at baseline and again after 6 weeks of fluvoxamine treatment. The anxiogenic effect of CO2 was significantly (p < .05) reduced during fluvoxamine treatment. The results suggest a relationship between the anxiogenic effect of CO2 and the therapeutic effect of fluvoxamine.
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