Fluvoxamine for fatigue in primary biliary cirrhosis and primary sclerosing cholangitis: a randomised controlled trial [ISRCTN88246634

BMC Gastroenterology
Pieter C J ter BorgHenk R van Buuren

Abstract

Fatigue is a major clinical problem in many patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). An effective treatment has not been defined. Recently, a large proportion of patients with these diseases was found to have symptoms of depression. Because fatigue is a frequent symptom of depression and there is some evidence that treatment with an antidepressant improves fatigue in patients with fibromyalgia, we hypothesised that the antidepressant fluvoxamine might improve fatigue related to PBC and PSC. Fatigued patients were randomised to receive fluvoxamine (75 mg BID) or placebo for a six-week period. Fatigue and quality of life were quantified using a visual analogue scale, the Fisk Fatigue Severity Scale, the Multidimensional Fatigue Inventory and the SF-36. Seventeen and 16 patients were allocated to fluvoxamine and placebo, respectively. There was no statistically significant beneficial effect of fluvoxamine on fatigue or quality of life. The median VAS scores in the fluvoxamine and placebo groups were 7.40 and 7.45 at day 0, 6.9 and 7.15 at day 14, 7.45 and 7.65 at day 42 and 7.8 and 8.0 four weeks after treatment discontinuation. We found no evidence for a beneficial effect of fluvoxam...Continue Reading

References

Jan 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D FiskW F Schlech
Oct 9, 1998·British Journal of Cancer·E M SmetsJ C de Haes
Oct 17, 1998·Journal of Psychosomatic Research·E M SmetsJ C de Haes
Nov 21, 1998·Gut·K Cauch-DudekE J Heathcote
Nov 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·A J WeardenJ A Morris
Nov 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·A DealeS Wessely
Mar 10, 2000·The American Journal of Gastroenterology·P M HuetJ Charbonneau
Oct 13, 2000·Journal of General Internal Medicine·P G O'MalleyJ L Jackson
Mar 1, 2002·The Cochrane Database of Systematic Reviews·C Gluud, E Christensen
Aug 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A VermaM Pazianas
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Oct 3, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Pierre-Michel HuetJacline Huet-Van Kerckvoorde

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Citations

Mar 17, 2007·European Journal of Applied Physiology·Berbke T J van GinnekenHenk J Stam
May 12, 2010·Nature Reviews. Gastroenterology & Hepatology·Ghulam AbbasKeith D Lindor
Jul 16, 2009·Seminars in Immunopathology·Simon HohenesterUlrich Beuers
Mar 4, 2009·Digestive Diseases and Sciences·Phunchai CharatcharoenwitthayaKeith D Lindor
Jun 1, 2016·Scientifica·Xun Zhao, Philip Wong
Apr 5, 2011·Clinics and Research in Hepatology and Gastroenterology·Marco Carbone, James Neuberger
May 6, 2008·Clinics in Liver Disease·Piotr Milkiewicz
Apr 3, 2007·Journal of Hepatology·Erik van OsHenk R van Buuren
Apr 19, 2017·The Cochrane Database of Systematic Reviews·Francesca SaffiotiDouglas Thorburn
Mar 30, 2017·The Cochrane Database of Systematic Reviews·Francesca SaffiotiDouglas Thorburn
Mar 3, 2006·Current Gastroenterology Reports·Phunchai Charatcharoenwitthaya, Keith D Lindor
Dec 17, 2008·Digestive Diseases and Sciences·S Ian GanMarshall M Kaplan
Jun 11, 2014·American Journal of Therapeutics·James H TabibianKeith D Lindor
Dec 5, 2006·World Journal of Gastroenterology : WJG·Vasiliy-Ivanovich Reshetnyak
Feb 20, 2015·Current Opinion in Gastroenterology·Elisabeth M G de VriesCyriel Y Ponsioen
Jul 7, 2018·Health and Quality of Life Outcomes·Fatima IsaMelanie Calvert
Jun 23, 2016·Clinical Medicine Insights. Gastroenterology·Aditi KumarAmar Puttanna
Jan 12, 2019·Digestive Diseases and Sciences·Jennifer Y LeeAlan Bonder
Mar 22, 2021·Health and Quality of Life Outcomes·Elena MarcusBella Vivat
Feb 5, 2008·Clinics in Liver Disease·Gustav Paumgartner, Thomas Pusl

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