PMID: 7542052Mar 1, 1995Paper

Fluvoxamine treatment of alcoholic amnestic disorder

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
P R MartinM J Eckardt

Abstract

The serotonin uptake inhibitor fluvoxamine was assessed in treatment of alcohol-induced Korsakoff's syndrome (KS) using fixed (4 weeks, 200 mg/day) or individualized (6 weeks, plasma concentration > or = 400 ng/ml) dosing in randomized placebo-controlled double-blind crossover studies. Cognitive functions and concentrations of the major cerebrospinal fluid (CSF) metabolites of serotonin (5-HIAA), norepinephrine (MHPG), and dopamine (HVA) were determined in abstinent, nondepressed KS patients (aged 45-75), at baseline and placebo (3-4 weeks), and after 3-4 (n = 10) or 6 (n = 4) weeks of fluvoxamine administration. Fluvoxamine decreased CSF 5-HIAA compared to placebo (P < 0.003) without consistent changes in HVA or MHPG. Reductions in 5-HIAA correlated with improvements on the Wechsler Memory Scale Memory Quotient (P < 0.05), independent of effects on attention/vigilance or Beck Depression Inventory scores. Reductions in 5-HIAA correlated with plasma fluvoxamine (P < 0.03) only for fluvoxamine concentrations below 450 ng/ml. These findings suggest improvement of memory consolidation and/or retrieval in patients with Korsakoff's syndrome by fluvoxamine via serotonergic mechanisms.

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Citations

Aug 1, 1996·Alcoholism, Clinical and Experimental Research·R Z LittenJ Fertig
Mar 19, 2008·The International Journal of Neuropsychopharmacology·Younghoon CheonDai-Jin Kim
Nov 16, 2007·Journal of Geriatric Psychiatry and Neurology·John O Brooks, Jennifer C Hoblyn
Mar 20, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·T ReusterJ Oehler
Nov 5, 2005·Neuroscience and Behavioral Physiology·Yu P Sivolap
Jan 17, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A E BobrovA A Kursakov
Mar 6, 2021·Neuroscience and Biobehavioral Reviews·Nicolaj MistarzAngelina Isabella Mellentin

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