PMID: 2126219Nov 1, 1990Paper

Fluvoxamine/pimozide treatment of concurrent Tourette's and obsessive-compulsive disorder

The British Journal of Psychiatry : the Journal of Mental Science
P L DelgadoD S Charney

Abstract

A 25-year-old man with a history of Tourette's syndrome presented for treatment of OCD symptoms. Fluvoxamine worsened tics, led to coprolalia, and did not help the OCD. The addition of pimozide dramatically reduced both OCD and Tourette's symptoms. Double-blind sequential discontinuation of fluvoxamine and pimozide confirmed that pimozide alone reduced only tics and the combination of fluvoxamine and pimozide was required for the improvement in OCD. Tics may reflect a subtype of OCD. Some OCD patients unresponsive to a 5-HT reuptake inhibitor alone may benefit from the addition of a dopamine antagonist.

References

Mar 1, 1979·Annals of Neurology·E D CaineE J Mikkelsen
Jan 1, 1976·Journal of the American Academy of Child Psychiatry·T Shapiro, H F Huebner
Jan 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Sep 1, 1988·The American Journal of Psychiatry·M A RiddleD J Cohen
Nov 1, 1988·Chemistry and Physics of Lipids·J DabrowskiT Ogawa
Dec 3, 1985·European Journal of Pharmacology·S KorsgaardE Christensson
Sep 1, 1981·Journal of Clinical Psychopharmacology·T R Insel, D L Murphy
Nov 1, 1980·Archives of General Psychiatry·P ThorénL Träskman

❮ Previous
Next ❯

Citations

Jun 1, 1995·Metabolic Brain Disease·P R ChokkaC M de Groot
Jan 1, 1995·European Archives of Psychiatry and Clinical Neuroscience·W PichotM Ansseau
Mar 30, 2011·European Child & Adolescent Psychiatry·Veit RoessnerUNKNOWN ESSTS Guidelines Group
Jan 5, 2001·European Child & Adolescent Psychiatry·M M Robertson, J S Stern
Jan 30, 1999·Journal of Psychoactive Drugs·P L Delgado, F A Moreno
Aug 6, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·C Lenti
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dennis L MurphyKiara R Timpano
Jan 5, 2002·Drugs·F J Jiménez-Jiménez, P J García-Ruiz
May 1, 1994·Journal of Child Psychology and Psychiatry, and Allied Disciplines·M M Robertson
Jan 1, 1995·Journal of Psychopharmacology·G B BakerR A Bornstein
Apr 1, 2008·Brain Stimulation·Mark S GeorgeJames C Ballenger
Apr 30, 2005·The Australian and New Zealand Journal of Psychiatry·Richard J KeunemanDavid J Castle
Jul 28, 2005·Behavior Modification·Charles S Mansueto, David J Keuler
Mar 16, 2006·Advances in Neurology·Ana Gabriela HounieEuripedes Constantino Miguel
Oct 29, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Amin Azzam, Carol A Mathews
Apr 7, 2005·International Clinical Psychopharmacology·Abdurrahman AltindagMehmet Asoglu
Dec 1, 2005·Expert Opinion on Pharmacotherapy·Bernardo Dell'OssoEric Hollander
Oct 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·D Jadresic
Jun 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·S FennigA Weitzman
Mar 23, 2002·Journal of Clinical Psychopharmacology·Zeruesenay DestaDavid A Flockhart
Jan 5, 2001·European Child & Adolescent Psychiatry·P H Thomsen
Dec 20, 2002·International Clinical Psychopharmacology·Giuseppe MainaFilippo Bogetto
Sep 15, 2006·Journal of Child Neurology·Wayne K GoodmanTanya K Murphy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.