FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy.

Circulation Research
Esther S H KimSanthi K Ganesh

Abstract

Multifocal fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection are both sex-biased diseases disproportionately affecting women over men in a 9:1 ratio. Traditionally known in the context of renovascular hypertension, recent advances in knowledge about FMD have demonstrated that FMD is a systemic arteriopathy presenting as arterial stenosis, aneurysm, and dissection in virtually any arterial bed. FMD is also characterized by major cardiovascular presentations including hypertension, stroke, and myocardial infarction. Similar to FMD, spontaneous coronary artery dissection is associated with a high prevalence of extracoronary vascular abnormalities, including FMD, aneurysm, and extracoronary dissection, and recent studies have also found genetic associations between the two diseases. This review will summarize the relationship between FMD and spontaneous coronary artery dissection with a focus on common clinical associations, histopathologic mechanisms, genetic susceptibilities, and the biology of these diseases. The current status of disease models and critical future research directions will also be addressed.

References

May 1, 1977·Annals of Internal Medicine·P MajorO Kuchel
Oct 1, 1987·Mayo Clinic Proceedings·T F LüscherS G Sheps
Apr 1, 1984·Disease-a-month : DM·J C Stanley, W M Whitehouse
Feb 1, 1980·Clinical Genetics·K GladstienK K Kidd
Mar 9, 2000·The New England Journal of Medicine·M PepinP H Byers
Feb 12, 2002·The American Journal of Cardiology·Akiko MaeharaNeil J Weissman
Apr 12, 2003·Science·Philippe BoucherJoachim Herz
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Mar 3, 2007·Journal of Human Hypertension·J PerduX Jeunemaitre
Jun 9, 2007·Orphanet Journal of Rare Diseases·Pierre-François PlouinXavier Jeunemaitre
Feb 10, 2009·Nature Genetics·UNKNOWN Myocardial Infarction Genetics ConsortiumDavid Altshuler
May 8, 2010·Heart·Christian J M Vrints
Nov 8, 2011·American Journal of Human Genetics·Matthew J BownNilesh J Samani
Dec 7, 2011·Circulation·Christopher J O'DonnellJacqueline C M Witteman
Feb 18, 2012·Circulation. Cardiovascular Interventions·Aditya M Sharma, Heather L Gornik
Mar 17, 2012·Journal of the American College of Cardiology·Fernando AlfonsoCarlos Macaya
Jun 12, 2012·Nature Genetics·Tobias FreilingerUNKNOWN International Headache Genetics Consortium
Dec 4, 2012·Nature Genetics·Panos DeloukasNilesh J Samani
Mar 19, 2013·The Canadian Journal of Cardiology·Jacqueline Saw
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Jun 26, 2013·Nature Genetics·Verneri AnttilaAarno Palotie
Jul 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Selen C MuratogluDudley K Strickland
Nov 15, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jacqueline Saw
Dec 21, 2013·The Journal of Clinical Investigation·Elena M GalloHarry C Dietz
Mar 4, 2014·European Heart Journal. Acute Cardiovascular Care·Tsuyoshi NishiguchiTakashi Akasaka
Apr 15, 2014·The Canadian Journal of Cardiology·Jacqueline SawDonald Ricci
Apr 16, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Santhi K GaneshNazli B McDonnell
Jul 26, 2014·JACC. Cardiovascular Interventions·Mathieu LempereurJacqueline Saw
Nov 20, 2014·Circulation. Cardiovascular Interventions·Marysia S TweetRajiv Gulati
Nov 25, 2014·Nature Genetics·Stéphanie DebetteUNKNOWN CADISP Group
Mar 24, 2015·JAMA Internal Medicine·Kashish GoelSharonne N Hayes

❮ Previous
Next ❯

Citations

Jun 11, 2021·Circulation Research·Nicholas J Leeper, Naomi M Hamburg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Related Papers

The Veterinary Record
A AssinderR Russell
The Veterinary Record
I Richards
The Veterinary Record
A I Donaldson, P Kitching
© 2021 Meta ULC. All rights reserved