Fmoc-diphenylalanine as a suitable building block for the preparation of hybrid materials and their potential applications.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Carlo DiaferiaAntonella Accardo

Abstract

Due to its capability to self-assemble in self-supporting hydrogels (HG) under physiological conditions, Fmoc-FF is one of the most studied ultra-short peptide. The structural properties of the resulting hydrogel (mechanical rigidity, entanglement of the fibrillary network, and the thickness of the fibers) strictly depend on the experimental conditions used during the preparation. In the past few years, a broad range of applications in different fields, such as biomedical and industrial fields, have been proposed. However, the research on novel materials with enhanced mechanical properties, stability, and biocompatibility has brought about the development of novel Fmoc-FF-based hybrid systems, in which the ultra-short hydrogelator is combined with others entities such as polysaccharides, polymers, peptides, or organic molecules. The structural features and the potential applications of these novel hybrid materials, with particular attention to tissue engineering, drug delivery, and catalysis, are described here. The aim is to give the readers a tool to design new hybrid nanomaterials based on the Fmoc-FF dipeptide hydrogelator, with appropriate properties for specific applications.

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Citations

Nov 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana M Fuentes-CaparrósDave J Adams
Jul 9, 2020·Soft Matter·Carlo DiaferiaAntonella Accardo
Jun 18, 2020·Frontiers in Bioengineering and Biotechnology·Seema GuptaPradeep Kumar
Jul 25, 2020·Macromolecular Bioscience·Yuuki HataTakeshi Serizawa
Jul 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Brittany L AbrahamBradley L Nilsson
May 20, 2020·Chemistry : a European Journal·Edgar FuentesLorenzo Albertazzi
Jan 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Enric Mayans, Carlos Alemán
Jan 31, 2021·International Journal of Molecular Sciences·Daisuke FujiiYoshiaki Hirano
Mar 11, 2021·International Journal of Nanomedicine·Enrico GalloAntonella Accardo
Mar 19, 2021·Biomacromolecules·Ana M Fuentes-CaparrósDave J Adams
Mar 7, 2021·Biomolecules·Dylan E ParsonsVinit B Mahajan
Mar 23, 2021·Frontiers in Bioengineering and Biotechnology·Nicole BalascoAntonella Accardo
Mar 27, 2021·Chemistry : a European Journal·Han CuiJinghua Chen
Apr 13, 2021·ACS Nano·Oren Ben-ZviLihi Adler-Abramovich
May 18, 2021·Journal of the American Chemical Society·Tinna PálmadóttirSara Linse
Jun 15, 2021·ACS Biomaterials Science & Engineering·Kate FiripisRichard J Williams
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pasqualina Liana ScognamiglioGiovanni Nicola Roviello
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Sep 30, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Harsimran KaurSangita Roy
Sep 4, 2021·Chemical Science·Tomoya YamamotoKatsunori Tanaka
Nov 17, 2021·Chembiochem : a European Journal of Chemical Biology·Ottavia BellottoSilvia Marchesan

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Methods Mentioned

BETA
peptide
Light microscopy
transmission electron microscopies
biosensors
circular dichroism
AFM
cross-linked hybrid
Confocal microscopy
biosensing

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