FMRFamide-gated sodium channel and ASIC channels: a new class of ionotropic receptors for FMRFamide and related peptides

Peptides
E LinguegliaM Lazdunski

Abstract

FMRFamide and related peptides typically exert their action through G-protein coupled receptors. However, two ionotropic receptors for these peptides have recently been identified. They are both members of the epithelial amiloride-sensitive Na+ channel and degenerin (ENaC/DEG) family of ion channels. The invertebrate FMRFamide-gated Na+ channel (FaNaC) is a neuronal Na+-selective channel which is directly gated by micromolar concentrations of FMRFamide and related tetrapeptides. Its response is fast and partially desensitizing, and FaNaC has been proposed to participate in peptidergic neurotransmission. On the other hand, mammalian acid-sensing ion channels (ASICs) are not gated but are directly modulated by FMRFamide and related mammalian peptides like NPFF and NPSF. ASICs are activated by external protons and are therefore extracellular pH sensors. They are expressed both in the central and peripheral nervous system and appear to be involved in many physiological and pathophysiological processes such as hippocampal long-term potentiation and defects in learning and memory, acquired fear-related behavior, retinal function, brain ischemia, pain sensation in ischemia and inflammation, taste perception, hearing functions, and mec...Continue Reading

References

Aug 12, 1977·Science·D A Price, M J Greenberg
Oct 2, 1992·Brain Research·J ZhuH Y Yang
Jul 1, 1992·Neuropeptides·R B Raffa, C D Connelly
Jul 1, 1990·Pflügers Archiv : European journal of physiology·G A CottrellN W Davies
Jul 31, 1990·Neuroscience Letters· Kovalchuk YuNM C Nowycky
Dec 1, 1989·Journal of Neuroscience Research·H SontheimerH Kettenmann
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·G A Cottrell
Jan 1, 1987·The Journal of Physiology·G A Cottrell, N W Davies
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H Y YangE Costa
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J TangE Costa
May 1, 1994·Progress in Neurobiology·N Akaike, S Ueno
Oct 1, 1994·Pflügers Archiv : European journal of physiology·K A GreenG A Cottrell
Dec 12, 1994·European Journal of Pharmacology·J P Devillers, G Simonnet
Jan 1, 1995·Experimental Physiology·S J Harris, G A Cottrell
Feb 1, 1994·Molecular and Cellular Neurosciences·M MacdonaldJ Sommerville
Apr 5, 1996·The Journal of Biological Chemistry·M P PriceM J Welsh
Mar 1, 1996·Progress in Neurobiology·P PanulaK Wasowicz
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J García-AñoverosD P Corey
Mar 13, 1997·Nature·R WaldmannM Lazdunski
Aug 22, 1997·The Journal of Biological Chemistry·R WaldmannM Lazdunski
Nov 14, 1997·Brain Research. Developmental Brain Research·Y X LiJ L Barker
Dec 31, 1997·The Journal of Biological Chemistry·E LinguegliaM Lazdunski
May 9, 1998·The Journal of Biological Chemistry·S CoscoyP Barbry
May 23, 1998·The Journal of Biological Chemistry·I DarbouxM Lazdunski
May 8, 1998·Biochemical and Biophysical Research Communications·K Ishibashi, F Marumo
May 21, 1998·European Journal of Pharmacology·M Roumy, J M Zajac

❮ Previous
Next ❯

Citations

Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Jan 19, 2011·ACS Chemical Neuroscience·Wei-Guang Li, Tian-Le Xu
Jul 17, 2007·Nature Neuroscience·Michel MazzucaMichel Lazdunski
Mar 11, 2011·The Journal of Biological Chemistry·Lindsey A TolinoMarcelo D Carattino
Nov 20, 2012·The Journal of Biological Chemistry·Qian WangXing-Zhen Chen
Apr 30, 2009·The Journal of Biological Chemistry·Thomas R KleymanRebecca P Hughey
Dec 5, 2006·Current Opinion in Nephrology and Hypertension·Michael H Humphreys
Jun 29, 2011·Current Opinion in Nephrology and Hypertension·Marcelo D Carattino
Feb 20, 2014·The Journal of Physical Chemistry. a·Charly Mayeux, Peeter Burk
Jan 15, 2014·The Journal of Physiological Sciences : JPS·Yu Kodani, Yasuo Furukawa
Feb 14, 2013·The Journal of Biological Chemistry·Nina BoikoJames D Stockand
May 1, 2010·Expert Review of Clinical Pharmacology·Jacques NoëlEric Lingueglia
Jun 18, 2014·Journal of Molecular Biology·Stephan Kellenberger, Thomas Grutter
Feb 7, 2012·Current Opinion in Neurobiology·Michael P Nusbaum, Dawn M Blitz
Jan 5, 2011·European Journal of Pharmacology·Michael H HumphreysDavid Pearce
Sep 3, 2010·Pharmacology & Therapeutics·Emmanuel DevalEric Lingueglia
Oct 1, 2008·Biochemical and Biophysical Research Communications·Mireya L Herrera-Herrera, Luis A Salazar-Olivo
Feb 5, 2008·Peptides·Estuardo López-VeraEdgar P Heimer de la Cotera
Sep 15, 2007·Neuropeptides·Hsiu-Ying T YangMichael J Iadarola
Jul 31, 2007·Biological Psychiatry·Matthew W CoryellJohn A Wemmie
Mar 1, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Stefania E NavoneEugenio A Parati
Feb 18, 2014·British Journal of Pharmacology·Stephen P H AlexanderUNKNOWN CGTP Collaborators
Nov 20, 2015·Neurochemical Research·Yinghong WangYan Huang
Jan 24, 2015·Neuropharmacology·Anne Baron, Eric Lingueglia
Mar 23, 2011·Biochimica Et Biophysica Acta·Raul MolinaHong-Long Ji
Jan 17, 2015·Neuropharmacology·François M Abboud, Christopher J Benson
Feb 22, 2012·Neuroscience Letters·Francisco MercadoRosario Vega
Nov 12, 2014·Frontiers in Endocrinology·Celine Zatylny-Gaudin, Pascal Favrel
Oct 18, 2014·Frontiers in Endocrinology·Safia Ayachi, Frédéric Simonin
Jun 10, 2016·British Journal of Pharmacology·Emilie BoscardinStephan Kellenberger
Nov 11, 2015·Channels·Yingjun GuoNie Lin
May 14, 2016·Physiological Reports·Zuhal ErgonulLawrence G Palmer
May 11, 2010·Pharmaceuticals·Qihai Gu, Lu-Yuan Lee
Sep 21, 2007·Nature·Jayasankar JastiEric Gouaux
Jun 23, 2006·Journal of Neurophysiology·Francisco MercadoEnrique Soto
Apr 14, 2007·The Journal of Biological Chemistry·Eric Lingueglia

❮ Previous
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