FMRFamide-related peptides and serotonin regulate Drosophila melanogaster heart rate: mechanisms and structure requirements

Peptides
R Nichols

Abstract

Drosophila melanogaster FMRFamide-related peptides (FaRPs) include SDNFMRFamide, PDNFMRFamide, and TDVDHVFLRFamide (dromyosuppressin, DMS); each peptide contains a C-terminal FMRFamide but a different N-terminal extension. FaRPs and serotonin (5-HT) each affect the frequency of D. melanogaster heart contractions in vivo. We examined the cellular expression of FaRPs and 5-HT, and the activities of FMRFamide, SDNFMRFamide, PDNFMRFamide, or DMS and 5-HT on heart rate. FaRPs and 5-HT were not co-localized; FaRP-and 5-HT-immunoreactive fibers extended from different brain cells and innervated the anterior D. melanogaster dorsal vessel. However, no neuron expressed both a FaRP and 5-HT. The effect of FMRFamide and 5-HT was not different from the effect of 5-HT alone on heart rate. The effect of PDNFMRFamide and 5-HT showed an additive effect on heart rate. SDNFMRFamide and 5-HT or DMS and 5-HT resulted in non-additive effects on heart rate. Our data provide evidence for the complexity of FaRP and 5-HT interactions to regulate frequency of heart contractions in vivo. Our results also confirm the biological importance of FaRP N-terminal amino acid extensions.

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Citations

Mar 2, 2010·Invertebrate Neuroscience : in·Robert J WalkerLindy Holden-Dye
Apr 22, 2014·General and Comparative Endocrinology·Julián F HillyerLauren E de la Parte
Feb 15, 2012·The Journal of Cell Biology·Xu Chen, Barry Ganetzky
Jun 25, 2010·The Journal of Comparative Neurology·Mikael A CarlssonDick R Nässel
Apr 23, 2015·Integrative and Comparative Biology·Julián F Hillyer
Jun 24, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Julián F HillyerHoma E Mirzai
Apr 22, 2015·PloS One·María José Villalobos-SambucaroJorge Rafael Ronderos
Dec 25, 2008·Journal of Neurogenetics·Konstantin G Iliadi
Oct 6, 2019·Annual Review of Entomology·Julián F Hillyer, Günther Pass
Jun 21, 2020·The Journal of Experimental Biology·Tania Y Estévez-LaoJulián F Hillyer
Feb 1, 2013·The Journal of Experimental Biology·Tania Y Estévez-LaoJulián F Hillyer

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