fMRI contrast at high and ultrahigh magnetic fields: insight from complementary methods

NeuroImage
Luisa CiobanuLucio Frydman

Abstract

This manuscript examines the origins and nature of the function-derived activation detected by magnetic resonance imaging at ultrahigh fields using different encoding methods. A series of preclinical high field (7 T) and ultra-high field (17.2 T) fMRI experiments were performed using gradient echo EPI, spin echo EPI and spatio-temporally encoded (SPEN) strategies. The dependencies of the fMRI signal change on the strength of the magnetic field and on different acquisition and sequence parameters were investigated. Artifact-free rat brain images with good resolution in all areas, as well as significant localized activation maps upon forepaw stimulation, were obtained in a single scan using fully refocused SPEN sequences devoid of T2* effects. Our results showed that, besides the normal T2-weighted BOLD contribution that arises in spin-echo sequences, fMRI SPEN signals contain a strong component caused by apparent T1-related effects, demonstrating the potential of such technique for exploring functional activation in rodents and on humans at ultrahigh fields.

References

Oct 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Ogawa, T M Lee
Jun 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D Kunz
Jan 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J G Pipe
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Gruetter
Oct 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S KanayamaK Satoh
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K UğurbilA Georgopoulos
Feb 12, 2002·Nature Reviews. Neuroscience·David J Heeger, David Ress
Jun 20, 2003·NeuroImage·R DeichmannR Turner
Feb 24, 2004·Annual Review of Physiology·Nikos K Logothetis, Brian A Wandell
May 2, 2006·Journal of Magnetic Resonance Imaging : JMRI·David G Norris
Jun 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robin A de GraafDouglas L Rothman
Sep 28, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ryan ChamberlainMichael Garwood
Jul 18, 2009·Magnetic Resonance Imaging·Noam Ben-EliezerLucio Frydman
Sep 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Govind B ChavhanE Mark Haacke
Jul 30, 2010·Progress in Nuclear Magnetic Resonance Spectroscopy·Assaf Tal, Lucio Frydman
Aug 12, 2010·NeuroImage·Ute GoerkeKamil Ugurbil
Aug 21, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Antti M AiraksinenOlli Gröhn
Mar 2, 2011·NMR in Biomedicine·Noam Ben-Eliezer, Lucio Frydman
Oct 20, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David G NorrisMarkus Barth
Oct 25, 2011·NeuroImage·Jia-Hong Gao, Ho-Ling Liu
Nov 16, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter A BandettiniRobert Turner
Jan 11, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robin M HeidemannRobert Turner
Jan 17, 2012·NeuroImage·David G Norris
Feb 16, 2012·NeuroImage·Kâmil Uğurbil
Jun 19, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ying ChenZhong Chen
Jul 14, 2012·Magnetic Resonance Imaging·Noam Ben-EliezerLucio Frydman
Mar 8, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rita Schmidt, Lucio Frydman
Oct 19, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Noam Ben-EliezerDaniel K Sodickson

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Citations

Mar 13, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eddy SolomonLucio Frydman
Mar 1, 2019·Scientific Reports·Yoshifumi AbeLuisa Ciobanu
Mar 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jae-Kyun RyuJang-Yeon Park
Nov 29, 2016·Frontiers in Neuroscience·José M SoaresNuno Sousa
Apr 28, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jianpan HuangShuhui Cai
May 26, 2017·Physical Chemistry Chemical Physics : PCCP·Sina MarhabaiePhilippe Pelupessy
Oct 28, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jae-Kyun RyuJang-Yeon Park

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