fMRI of supraspinal areas after morphine and one week pancreatic inflammation in rats.

NeuroImage
Karin N WestlundCharles S Cleeland

Abstract

Abdominal pain is a major reason patients seek medical attention yet relatively little is known about neuronal pathways relaying visceral pain. We have previously characterized pathways transmitting information to the brain about visceral pain. Visceral pain arises from second order neurons in lamina X surrounding the spinal cord central canal. Some of the brain regions of interest receiving axonal terminations directly from lamina X were examined in the present study using enhanced functional magnetic resonance imaging (fMRI) before and one week after induction of a rat pancreatitis model with persistent inflammation and behavioral signs of increased nociception. Analysis of imaging data demonstrates an increase in MRI signal for all the regions of interest selected including the rostral ventromedial medulla, dorsal raphe, periaqueductal grey, medial thalamus, and central amygdala as predicted by the anatomical data, as well as increases in the lateral thalamus, cingulate/retrosplenial and parietal cortex. Occipital cortex was not activated above threshold in any condition and served as a negative control. Morphine attenuated the MRI signal, and the morphine effect was antagonized by naloxone in lower brainstem sites. These da...Continue Reading

Citations

Sep 11, 2009·Journal of Neurophysiology·Changfeng TaiWilliam C de Groat
Apr 17, 2009·Journal of Neurophysiology·Yong RenKarin N Westlund
Mar 27, 2012·Neuroscience Letters·Scott J Thompson, M Catherine Bushnell
Dec 4, 2010·Neuroscience and Biobehavioral Reviews·David Borsook, Lino Becerra
May 20, 2011·Basic & Clinical Pharmacology & Toxicology·Camilla StaahlAsbjørn M Drewes
Jul 14, 2010·European Journal of Pain : EJP·Ulises CoffeenFrancisco Pellicer
Sep 20, 2011·Pharmacology, Biochemistry, and Behavior·Ana Carolina RossaneisWiliam A Prado
Jun 19, 2016·Molecular Pain·Catherine S HubbardRichard J Traub
Apr 29, 2021·The European Journal of Neuroscience·Karina Genaro, Wiliam A Prado

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