FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control

Proceedings of the National Academy of Sciences of the United States of America
Indulekha P SudhakaranMani Ramaswami

Abstract

Fragile X mental retardation protein (FMRP) and Ataxin-2 (Atx2) are triplet expansion disease- and stress granule-associated proteins implicated in neuronal translational control and microRNA function. We show that Drosophila FMRP (dFMR1) is required for long-term olfactory habituation (LTH), a phenomenon dependent on Atx2-dependent potentiation of inhibitory transmission from local interneurons (LNs) to projection neurons (PNs) in the antennal lobe. dFMR1 is also required for LTH-associated depression of odor-evoked calcium transients in PNs. Strong transdominant genetic interactions among dFMR1, atx2, the deadbox helicase me31B, and argonaute1 (ago1) mutants, as well as coimmunoprecitation of dFMR1 with Atx2, indicate that dFMR1 and Atx2 function together in a microRNA-dependent process necessary for LTH. Consistently, PN or LN knockdown of dFMR1, Atx2, Me31B, or the miRNA-pathway protein GW182 increases expression of a Ca2+/calmodulin-dependent protein kinase II (CaMKII) translational reporter. Moreover, brain immunoprecipitates of dFMR1 and Atx2 proteins include CaMKII mRNA, indicating respective physical interactions with this mRNA. Because CaMKII is necessary for LTH, these data indicate that fragile X mental retardation ...Continue Reading

References

Jan 1, 1966·Experimental Neurology·W RallM W Brightman
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·M MayfordE R Kandel
May 15, 1998·Neuron·J S Isaacson, B W Strowbridge
Nov 26, 1998·Acta Neuropathologica·S D GinsbergJ Q Trojanowski
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·T AchselR Lührmann
Apr 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ItoY Sakaki
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·W T GreenoughI J Weiler
Jun 8, 2002·Annual Review of Neuroscience·William T O'Donnell, Stephen T Warren
Oct 9, 2002·Genes & Development·Amy A CaudyScott M Hammond
Oct 9, 2002·Genes & Development·Akira IshizukaHaruhiko Siomi
Dec 6, 2003·Science·Sean E McGuireRonald L Davis
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura N AntarGary J Bassell
Jun 29, 2004·Trends in Neurosciences·Mark F BearStephen T Warren
Aug 25, 2004·American Journal of Medical Genetics. Part a·Walter E KaufmannPia Stanard
Jan 25, 2005·Journal of Molecular Biology·Markus RalserSylvia Krobitsch
Apr 13, 2005·Current Biology : CB·Shouzhen XiaAnn-Shyn Chiang
Apr 30, 2005·Nature Reviews. Neuroscience·Claudia Bagni, William T Greenough
May 11, 2005·Journal of Neurobiology·Michael A Sutton, Erin M Schuman
Dec 15, 2005·Molecular & Cellular Proteomics : MCP·George ElviraWayne S Sossin
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kelsey C Martin, R Suzanne Zukin
Jul 13, 2006·Human Molecular Genetics·Terrence F Satterfield, Leo J Pallanck
Sep 20, 2006·Neuron·Michael A Kiebler, Gary J Bassell
Oct 24, 2006·Traffic·Wayne S Sossin, Luc DesGroseillers
Mar 30, 2007·Molecular Biology of the Cell·Ute NonhoffSylvia Krobitsch
Apr 10, 2007·Annual Review of Neuroscience·Harry T Orr, Huda Y Zoghbi
Aug 19, 2007·Neuron·Maurice S Swanson, Harry T Orr
Sep 13, 2007·Nature Reviews. Neuroscience·Clive R Bramham, David G Wells
Oct 24, 2007·Molecular & Cellular Proteomics : MCP·Ulrich RothbauerHeinrich Leonhardt

❮ Previous
Next ❯

Citations

Aug 5, 2014·Trends in Neurosciences·A J Robison
Nov 26, 2015·Neuroscience and Biobehavioral Reviews·Juan F Codocedo, Nibaldo C Inestrosa
Oct 23, 2015·Brain : a Journal of Neurology·Clévio NóbregaLuís Pereira de Almeida
Apr 2, 2016·Neural Plasticity·Yuqin YeXiaosheng He
Apr 29, 2015·Chemical Senses·Arielle Schilit NitensonKevin G Bath
Aug 20, 2016·The Journal of Comparative Neurology·Diego A R ZorioYuan Wang
Oct 12, 2016·RNA Biology·Indulekha P Sudhakaran, Mani Ramaswami
Oct 30, 2016·Chronobiology International·Martina PfefferHorst-Werner Korf
Nov 13, 2016·Current Opinion in Neurobiology·Germain U BustoRonald L Davis
Jan 25, 2017·Trends in Endocrinology and Metabolism : TEM·Sara Carmo-SilvaClaudia Cavadas
Feb 7, 2016·Molecular & Cellular Proteomics : MCP·David MeierhoferGeorg Auburger
Sep 30, 2016·Journal of Neurophysiology·Randall M Golovin, Kendal Broadie
Jun 6, 2018·Wiley Interdisciplinary Reviews. RNA·Jongbo LeeChunghun Lim
Sep 21, 2018·ASN Neuro·Maham RaisIryna M Ethell
Jul 17, 2014·BMC Research Notes·Domingo Jiménez-López, Plinio Guzmán
Feb 7, 2020·International Journal of Molecular Sciences·Marten HansenEwa Rollmann
May 2, 2018·Frontiers in Molecular Neuroscience·Małgorzata DrozdMaria Capovilla
Aug 24, 2019·International Journal of Molecular Sciences·Ibuki UeokaMasamitsu Yamaguchi
Mar 3, 2020·Frontiers in Molecular Biosciences·Bharti NawalpuriRavi S Muddashetty
Dec 6, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shoi Shi, Hiroki R Ueda
Jan 22, 2019·Nature Cell Biology·Stephanie L MoonTimothy J Stasevich
May 16, 2019·Disease Models & Mechanisms·Mireia Coll-TanéAnnette Schenck
Mar 12, 2020·Frontiers in Physiology·Yiming Bai, Takashi Suzuki
Sep 17, 2020·International Journal of Molecular Sciences·Aleksandar ArsovićGeorg Auburger
Jun 8, 2017·Genes·Lauren A OstrowskiKarim Mekhail
Sep 29, 2017·Frontiers in Neurology·Luis C Velázquez-PérezJuan Fernandez-Ruiz
Jun 14, 2019·Frontiers in Molecular Neuroscience·Felipe BodaleoAlexia Nunez-Parra
Nov 17, 2020·The Journal of Cell Biology·Pearl V RyderDorothy A Lerit
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Pureum Jeon, Jin A Lee
Apr 17, 2021·Frontiers in Behavioral Neuroscience·Camilla RoselliIsaac Cervantes-Sandoval
May 20, 2021·Current Opinion in Neurology·Jose Miguel Laffita-MesaPer Svenningsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved