Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice.

American Journal of Respiratory Cell and Molecular Biology
Halvor S McGeeDevendra K Agrawal

Abstract

We previously reported that Fms-like tyrosine kinase 3 ligand (Flt3-L) reversed airway hyperresponsiveness (AHR) and airway inflammation, and increased the number of regulatory CD11c(high)CD8α(high)CD11b(low) dendritic cells and CD4(+)CD25(+)ICOS(+)Foxp3(+)IL-10(+) T-regulatory cells in the lung of allergen-sensitized and -challenged mice. In this study, we evaluated the effect of Flt3-L on Th17 cells and expression of suppressors of cytokine signaling (SOCS) proteins in the lungs of house dust mite (HDM)-sensitized and -challenged mice. BALB/c mice were sensitized and challenged with HDM, and AHR to methacholine was established. Mice were treated with Flt3-L (5 μg, intraperitoneal) daily for 10 days. Levels of IL-4, -5, -6, -8, and -13, and transforming growth factor (TGF)-β in the bronchoalveolar lavage fluid (BALF) were examined by ELISA. Flt3-L treatment reversed existing AHR to methacholine and substantially decreased eosinophils, neutrophils, IL-5, -6, -8, and IL-13, and TGF-β levels in the BALF. HDM-sensitized and -challenged mice showed a significant increase in lung CD4(+)IL-17(+)IL-23R(+)CD25⁻ T cells with high expression of retinoic acid-related orphan receptor (ROR)-γt transcripts. However, administration of Flt3-L ...Continue Reading

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Citations

Apr 25, 2012·Journal of Clinical Immunology·Tanupriya AgrawalDevendra K Agrawal
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Feng LanPing Lin
Jun 17, 2014·International Immunopharmacology·Sannette Hall, Devendra K Agrawal
Jan 24, 2014·Current Opinion in Immunology·Mary J van Helden, Bart N Lambrecht
Apr 28, 2012·Experimental and Molecular Pathology·Tanupriya AgrawalDevendra K Agrawal
Nov 22, 2014·Respiratory Research·Kimberly D Fischer, Devendra K Agrawal
Jan 22, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K ManeechotesuwanP J Barnes
May 2, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yanchun Li, Shucheng Hua
Oct 17, 2013·Expert Review of Clinical Immunology·Rohit Gaurav, Devendra K Agrawal

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