FNAC accuracy in diagnosis of thyroid neoplasms considering all diagnostic categories of the Bethesda reporting system: A single-institute experience

Journal of Cytology
Fatemeh Hajmanoochehri, Elham Rabiee

Abstract

Thyroid fine-needle aspiration cytology (FNAC) is a valuable test used for diagnosing diseases of the thyroid gland. Using all satisfactory categories of the Bethesda system, this study aimed to determine the accuracy with which FNAC diagnoses thyroid neoplasms. We also discuss the factors that affect diagnosis accuracy. A comparison was drawn between FNAC results and final histological diagnosis using samples collected over a period of 3 years. For all patients, age, sex, cytological features, and histological types were determined. All cases of false negative (FN) and false positive (FP) diagnosis were reanalyzed. The chi-square test and univariate analysis were performed to examine the relationship between different variables. About 52% of the cases were found malignant, and they were of six different histological types. Papillary carcinoma was the commonest type of malignancy at 76.9%. The rate of malignancy was 63% in males and 49.4% in females. In two of the FN cases, the tumor had a diameter of ≥35 mm. Of the 12 FP cases, nine were in the follicular neoplasm or suspicious for follicular neoplasm Bethesda category. FNAC diagnosis had 95.2% sensitivity, 68.4% specificity, 83.3% positive predictive value, 89.6% negative pre...Continue Reading

References

Oct 23, 2009·American Journal of Clinical Pathology·Edmund S CibasUNKNOWN NCI Thyroid FNA State of the Science Conference
Dec 7, 2010·Indian Journal of Cancer·P K Bagga, N C Mahajan
Apr 16, 2013·Journal of the Egyptian National Cancer Institute·E A Sinna, N Ezzat
Jul 9, 2013·Journal of Cytology·Santosh Kumar MondalSwapan Kumar Sinha

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Citations

Apr 26, 2017·World Journal of Clinical Oncology·Mohamed Abdulaziz Al DawishRim Braham
Oct 11, 2017·The Laryngoscope·Jan BoucekUNKNOWN International Network on Cancer, Infertility, and Pregnancy
Mar 17, 2017·PloS One·Sara FranceschiChiara Maria Mazzanti
Jul 22, 2020·International Journal of Surgery Case Reports·Sujeethra AlaguvelsamyRamalingam Kombupalayam Komarappa Gounder
Apr 30, 2021·Cytopathology : Official Journal of the British Society for Clinical Cytology·Tibor MezeiPhilippe Vielh

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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