FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Suman SrinivasaHideo Makimura

Abstract

To investigate the relationship of skeletal muscle FNDC5 mRNA expression and circulating irisin to the GH/IGF-I axis and to skeletal muscle mitochondrial function and mitochondria-related gene expression in obese men. Fifteen abdominally obese men with reduced growth hormone received 12weeks of recombinant human GH (rhGH). Before and after treatment, they underwent (31)P-magnetic resonance spectroscopy to evaluate phosphocreatine (PCr) recovery as a measure of mitochondrial function and skeletal muscle biopsy to assess expression of mitochondrial-related genes. Serum irisin and IGF-I and skeletal muscle FNDC5 and IGF-I mRNA were measured. At baseline, skeletal muscle FNDC5 mRNA was significantly and positively associated with IGF-I mRNA (ρ=0.81, P=0.005) and rate of PCr recovery (ρ=0.79, P=0.006). Similar relationships of circulating irisin to IGF-I mRNA (ρ=0.63, P=0.05) and rate of PCr recovery (ρ=0.48, P=0.08) were demonstrated, but were not as robust as those with muscle FNDC5 expression. Both serum irisin and skeletal muscle FNDC5 mRNA were significantly associated with PPARγ (ρ=0.73, P=0.02 and ρ=0.85, P=0.002), respectively. In addition, FNDC5 mRNA was correlated with skeletal muscle PGC-1α (ρ=0.68, P=0.03), NRF1 (ρ=0.66,...Continue Reading

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Citations

Jul 30, 2016·PloS One·Lara Pena-BelloFernando Cordido
Oct 4, 2016·Molecular and Cellular Endocrinology·Anji LianQuan Jiang
Jul 6, 2017·Physiological Reports·Brianne L GuilfordDouglas E Wright
Jan 25, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Fatemeh KazeminasabMohammad Hossein Nasr-Esfahani
Nov 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Alessandro CiresiCarla Giordano
Jun 4, 2019·Journal of Alzheimer's Disease : JAD·Jonathan A Zegarra-ValdiviaIgnacio Torres Aleman
Sep 18, 2020·Molecular and Cellular Endocrinology·Luis Fabián Canosa, Juan Ignacio Bertucci
Apr 2, 2021·International Journal of Endocrinology·Hui LiDongqi Tang

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