PMID: 12752523May 20, 2003Paper

Foam during reconstitution does not affect the potency of botulinum toxin type A

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Ada Regina Trindade De AlmeidaDalva Regina Neto

Abstract

Among factors that may affect the potency of botulinum toxin A (Botox), it is said that foam, together with bubbles, may cause surface denaturation of the toxin. To determine whether the muscle relaxation effect of Botox is preserved and has the same duration when it is reconstituted in the presence of foam. Six female volunteers, aged 42 to 56 years old, were treated for glabellar and periocular wrinkles. Each half of the face was treated with 16 U of Botox divided in four sites: three at the lateral orbital area and one at the medial brow, in the glabellar region. The right side received Botox gently reconstituted with saline to avoid foaming formation. The left side of the face was treated with Botox that was rapidly reconstituted in order to achieve as many bubbles as possible, even with shaking. Blinded observers compared pretreatment and posttreatment photographs and answered assessment-related questions. The results were analyzed clinically and statistically. There was no difference in muscle paralysis between treated sides in all patients, neither in early (15 days) nor late (4 months) follow-up evaluations. Botox maintains its potency even in the presence of foaming during the reconstitution process.

References

Feb 1, 1993·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M G Gartlan, H T Hoffman
Jul 1, 1997·International Ophthalmology Clinics·S R Carter, S R Seiff
Jul 25, 2000·Journal of the American Academy of Dermatology·W HuangA S Rogachefsky
Jul 28, 2001·Seminars in Cutaneous Medicine and Surgery·A Carruthers, J Carruthers
Aug 9, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·T C FlynnJ A Carruthers

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Citations

Feb 5, 2004·Clinics in Dermatology·Anthony V Benedetto
Oct 28, 2004·Plastic and Reconstructive Surgery·Jean CarruthersUNKNOWN Botox Consensus Group
Feb 3, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Debraj ShomeVandana Jain
Jul 23, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ada R Trindade De AlmeidaAlastair Carruthers
Jul 10, 2010·Middle East African Journal of Ophthalmology·Pelin Kaynak-Hekimhan
May 6, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Natalie L Semchyshyn, Suzanne L Kilmer
Aug 10, 2011·Clinics in Plastic Surgery·Todd V Cartee, Gary D Monheit
Feb 24, 2007·Facial Plastic Surgery Clinics of North America·Andrew S Frankel, Alex Markarian
Jul 2, 2016·Clinics in Plastic Surgery·Michael S Gart, Karol A Gutowski
Nov 4, 2010·Nature Reviews. Neurology·Erle C H Lim, Raymond C S Seet
Jun 24, 2008·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Ana Paula de Sa Earp, Ellen S Marmur

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