PMID: 6403683Feb 1, 1983Paper

Focal acantholytic dyskeratosis in experimental oral carcinogenesis in rats

Journal of Oral Pathology
H P Philipsen, A V Fisker

Abstract

Thrice weekly applications of carcinogen 4-nitroquinoline N-oxide to rat oral mucosa, induced focal acantholytic dyskeratosis (FAD) in about 50% of the animals. Mucosa overlying bone (palate and attached buccal gingiva) was the area of predilection. The number of oral foci per affected animal ranged between 1 and 3. Histologically, the experimental FAD foci showed all the characteristic features described for human focal acantholytic dyskeratosis. FAD appeared unrelated to malignancy development. It is suggested that FAD represents an induced epithelial differentiation or maturation defect caused by a variety of stimuli among which are chemical carcinogens. The present experimental model seems suitable for further histo- and cytopathogenetic studies.

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Citations

Jun 1, 1990·The Journal of Dermatologic Surgery and Oncology·S L Zunt, C E Tomich
Sep 23, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Irit Allon, Amos Buchner
Jun 1, 1983·Journal of Cutaneous Pathology·A V Fisker, H P Philipsen
Feb 1, 1989·Journal of Cutaneous Pathology·R V Kolbusz, D F Fretzin
Feb 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J ReibelE Dabelsteen
Feb 1, 1995·International Journal of Oral and Maxillofacial Surgery·J M NautaA Vermey
Jul 1, 1984·Oral Surgery, Oral Medicine, and Oral Pathology·A S Leider, L R Eversole
Mar 5, 1998·Journal of the American Academy of Dermatology·D J DiMaio, P R Cohen
Jan 22, 2002·The American Journal of Dermatopathology·J A CarlsonS Sell
Oct 1, 1984·Journal of Oral Pathology·M N Chau, B G Radden
Jan 1, 1986·Journal of Periodontal Research·P van der BijlS R Grobler
Jan 1, 1990·International Journal of Technology Assessment in Health Care·W J Loesche
Nov 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·A V Fisker, H P Philipsen

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