Focal activation of neuronal circuits induced by microstimulation in the visual cortex

Journal of Neural Engineering
Yuta TanakaTetsuya Yagi

Abstract

Microstimulation to the cortical tissue applied with penetrating electrodes delivers current that spreads concentrically around the electrode tip and is known to evoke focal visual sensations, i.e. phosphenes. However, to date, there is no direct evidence depicting the spatiotemporal properties of neuronal activity induced immediately after microstimulation and how such activity drives the subsequent local cortical circuits. In the present study, we imaged the spatiotemporal distribution of action potentials (APs) directly induced by microstimulation and the subsequent trans-synaptic signal propagation using a voltage-sensitive dye (VSD) and a calcium-sensitive dye (CaSD) in slice preparations of the mouse primary visual cortex. The directly induced APs were confined to the close vicinity of the electrode tip, and the effective distance of excitation was proportional to the square root of the current intensity. The excitation around the electrode tip in layer IV mainly propagated to layer II/III to further induce the subsequent focal activation in downstream local cortical circuits. The extent of activation in the downstream circuits was restrained by competitive interactions between excitatory and inhibitory signals. Namely, t...Continue Reading

References

Dec 22, 1976·Experimental Brain Research·H AsanumaP Zarzecki
May 1, 1990·Medical & Biological Engineering & Computing·M BakE M Schmidt
Jan 8, 1989·The Journal of Comparative Neurology·A Burkhalter
May 1, 1968·The Journal of Physiology·G S Brindley, W S Lewin
Mar 1, 1996·Journal of Neuroscience Methods·E J Tehovnik
Jun 5, 1999·Methods : a Companion to Methods in Enzymology·D SmettersR Yuste
Nov 11, 1999·The Journal of Membrane Biology·Y Momose-SatoK Kamino
Sep 25, 2002·The European Journal of Neuroscience·Edward J TehovnikPeter H Schiller
Feb 27, 2003·The European Journal of Neuroscience·Edward J TehovnikPeter H Schiller
Jul 25, 2003·Journal of Neurophysiology·Sergejus Butovas, Cornelius Schwarz
Mar 26, 2004·Nature·Dirk JanckeAmiram Grinvald
Sep 17, 2004·Journal of Neurophysiology·E J TehovnikP H Schiller
Oct 22, 2004·Nature Reviews. Neuroscience·Amiram Grinvald, Rina Hildesheim
Jan 22, 2005·Journal of Neuroscience Methods·Daniel R MerrillJohn G R Jefferys
Aug 5, 2005·Journal of Neurophysiology·Edgar A DeYoeRobert W Doty
Aug 5, 2005·Journal of Neurophysiology·John R BartlettWilliam H Overman
Dec 19, 2006·Brain Research Reviews·Edward J Tehovnik, Warren M Slocum
Mar 31, 2007·Cerebral Cortex·Dahlia SharonAmiram Grinvald
Apr 11, 2007·The European Journal of Neuroscience·Sergejus Butovas, Cornelius Schwarz
Apr 24, 2008·Annual Review of Biomedical Engineering·Stuart F Cogan
Nov 5, 2008·Frontiers in Neuroscience·Alex M Thomson, Christophe Lamy
Dec 11, 2008·Perception·Peter H Schiller, Edward J Tehovnik
Feb 20, 2009·IEEE Transactions on Bio-medical Engineering·Andrew A SharpKen Gall
May 22, 2009·Journal of Neural Engineering·Richard A NormannEduardo Fernandez
Jun 13, 2009·The European Journal of Neuroscience·Edward J Tehovnik, Warren M Slocum

❮ Previous
Next ❯

Citations

Jul 11, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Kevin A Mazurek, Marc H Schieber
Nov 14, 2021·Brain Structure & Function·Sabrina J Meikle, Yan T Wong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.