Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes.

Journal of Neurochemistry
Audrey D Lafrenaye, Babette Fuss

Abstract

During development cells of the oligodendrocyte lineage undergo significant changes in morphology when they differentiate from migratory oligodendrocyte progenitors, which are mostly bipolar, into post-migratory pre-myelinating oligodendrocytes, which extend complex and expanded process networks, and then finally into mature oligodendrocytes, which generate myelin sheaths required for efficient signal propagation within the nervous system. This extensive morphological remodeling occurs in the context of a complex extracellular environment and requires significant rearrangement of the cell's cytoskeleton. The molecular mechanisms underlying this intricate integration of signals, however, remain poorly understood. A key regulator of extracellular matrix to cytoskeleton signaling is the non-receptor tyrosine kinase FAK (focal adhesion kinase). Here, we report that FAK can regulate the morphology of differentiating post-migratory pre-myelinating oligodendrocytes in a unique and opposing fashion that is dependent on the nature of the extracellular matrix and mediated largely by FAK's catalytic activity. More specifically, FAK was found to restrict process network expansion in the presence of fibronectin but to promote morphological ...Continue Reading

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D SchallerJ T Parsons
Feb 1, 1986·The Journal of Cell Biology·M Dubois-DalcqR A Lazzarini
Jul 1, 1988·Journal of Neurochemistry·A T Campagnoni
Jan 1, 1981·Journal of Neuroscience Research·S R MackG Dawson
Aug 1, 1995·The European Journal of Neuroscience·F BurgayaJ A Girault
Jan 1, 1996·Developmental Neuroscience·R J Hardy, V L Friedrich
Nov 15, 1996·Journal of Neuroscience Research·G R StevensW L Klein
Feb 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S K Hanks, T R Polte
Nov 14, 1997·The Journal of Biological Chemistry·F BurgayaJ A Girault
Jan 8, 1998·The European Journal of Neuroscience·M L Fanarraga, E A Milward
Jun 4, 1999·Progress in Biophysics and Molecular Biology·D D SchlaepferD J Sieg
Jun 15, 1999·The Journal of Cell Biology·D J OsterhoutM V Chao
Aug 14, 1999·Science·F G Giancotti, E Ruoslahti
Nov 11, 1999·Current Biology : CB·E E FrostC ffrench-Constant
Nov 30, 1999·Molecular and Cellular Neurosciences·P C Buttery, C ffrench-Constant
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Apr 21, 2001·Molecular and Cellular Neurosciences·J SongI D Duncan
Sep 8, 2001·Progress in Brain Research·P C Buttery, C ffrench-Constant
Oct 16, 2002·Nature Cell Biology·Holly ColognatoCharles ffrench-Constant
Mar 5, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andrea ContestabileFlavia Valtorta
Mar 18, 2003·Journal of Cell Science·J Thomas Parsons
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Steven K HanksJan Brábek
Oct 29, 2003·The Journal of Cell Biology·Soo Jin ChunTimothy Vartanian
Jan 1, 2004·Australian Endodontic Journal : the Journal of the Australian Society of Endodontology Inc·Tom Berekally
Jun 1, 1993·Trends in Cell Biology·S E PfeifferR Bansal
Aug 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiquan LiangMarilyn D Resh
Sep 21, 2004·Nature Neuroscience·Beatriz RicoLouis F Reichardt
Oct 16, 2004·Molecular and Cellular Neurosciences·Michael A FoxBabette Fuss
Oct 19, 2004·Oncogene·Martin P Playford, Michael D Schaller
Oct 27, 2004·The Journal of Cell Biology·Holly ColognatoCharles ffrench-Constant
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Satyajit K MitraDavid D Schlaepfer

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Citations

Apr 6, 2013·Neuroscience Bulletin·Jared T Ahrendsen, Wendy Macklin
Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nobuharu SuzukiYoshihiko Yamada
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher T WaggenerBabette Fuss
Nov 29, 2011·Journal of Neurochemistry·Christopher EyermannHolly Colognato
Aug 13, 2011·Developmental Neurobiology·Holly Colognato, Iva D Tzvetanova
Mar 27, 2016·Experimental Neurology·Natalie A Wheeler, Babette Fuss
Jun 4, 2011·Journal of Signal Transduction·Ryan W O'MearaRashmi Kothary
Apr 12, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Anna Klingseisen, David A Lyons
Sep 30, 2014·The European Journal of Neuroscience·Beatriz G ArmendárizFerran Burgaya
Jul 11, 2020·Cellular and Molecular Life Sciences : CMLS·Inge L WerkmanWia Baron
Nov 14, 2021·Glia·Minkyung Kang, Yao Yao

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