Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.

Cell Host & Microbe
Rebecca A BozymCarolyn B Coyne

Abstract

Viruses modulate the actin cytoskeleton at almost every step of their cellular journey from entry to egress. Cellular sensing of these cytoskeletal changes may function in the recognition of viral infection. Here we show that focal adhesion kinase (FAK), a focal adhesion localized tyrosine kinase that transmits signals between the extracellular matrix and the cytoplasm, serves as a RIG-I-like receptor antiviral signaling component by directing mitochondrial antiviral signaling adaptor (MAVS) activation. Cells deficient in FAK are highly susceptible to RNA virus infection and attenuated in antiviral signaling. We show that FAK interacts with MAVS at the mitochondrial membrane in a virus infection-dependent manner and potentiates MAVS-mediated signaling via a kinase-independent mechanism. A cysteine protease encoded by enteroviruses cleaves FAK to suppress its role in innate immune signaling. These findings suggest that FAK serves as a link between cytoskeletal perturbations that occur during virus infection and activation of innate immune signaling.

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Citations

Sep 11, 2012·Cellular & Molecular Immunology·Hailei YinZhaocai Zhou
May 31, 2013·Journal of Virology·Elizabeth Delorme-AxfordCarolyn B Coyne
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth Delorme-AxfordCarolyn B Coyne
Mar 25, 2014·Annual Review of Immunology·Jiaxi Wu, Zhijian J Chen
Jan 14, 2016·International Journal of Molecular Sciences·Heather J EzelleBret A Hassel
Oct 15, 2013·Journal of Molecular Biology·Jana L Jacobs, Carolyn B Coyne
Jul 24, 2014·The FEBS Journal·Marie Pourcelot, Damien Arnoult
Jul 16, 2014·Cytokine & Growth Factor Reviews·Jessica J ChiangMichaela U Gack
Aug 2, 2014·Cytokine & Growth Factor Reviews·Susan E Collins, Karen L Mossman
Jun 27, 2013·Cytokine·David Hare, Karen L Mossman
May 28, 2013·Immunity·Delphine GoubauCaetano Reis e Sousa
Oct 29, 2015·PloS One·Katharine G Harris, Carolyn B Coyne
Sep 16, 2015·PLoS Pathogens·Qian ShuCarolyn B Coyne
Apr 4, 2014·Journal of Virology·Husni ElbaheshCharles J Russell
Feb 23, 2019·Viruses·Robert MeinekeHusni Elbahesh
Jun 20, 2018·Molecular Medicine Reports·Tian-Sheng HeLiang-Guo Xu
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Giulia RefoloFabiola Ciccosanti

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