Focal adhesion plaque associated cytoskeletons are involved in the invasion and metastasis of human colorectal carcinoma

Cancer Investigation
Hong-Jun YangYan-Qing Ding

Abstract

The protein and mRNA expression of focal adhesion plaque associated cytoskeletons, including talin, vinculin, paxillin, and tensin, was studied using immunofluorescence in combination with confocal laser scanning microscopy and fluorescent quantitative polymerase chain reaction in 41 matched samples of human normal colorectal mucosae, primary colorectal adenocarcinomas, and 19 separate lymph node metastases. All specimens showed expression. The results showed talin, vinculin, tensin, and paxillin expression were correlated with carcinogenesis, invasion, and metastasis of colorectal carcinoma (CRC). Talin, vinculin, and tensin underwent downregulation while paxillin went up. So these cytoskeletons may play bidirectional regulating roles during the progression of CRC.

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Jul 10, 2012·The Journal of Biological Chemistry·Hermann KalwaThomas Michel
Dec 15, 2010·Molecular Biology of the Cell·Nicholas O Deakin, Christopher E Turner
Dec 12, 2012·Genes & Cancer·Nicholas O DeakinChristopher E Turner
Jan 11, 2021·Pathology, Research and Practice·Xianchen LiuChong Tang
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Mar 6, 2013·Journal of Proteome Research·Susan FanayanEdouard Nice
Dec 2, 2021·Molecular Biology of the Cell·Weiyi XuChristopher E Turner

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