Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes.

Spermatogenesis
J'nelle S Young, A W Vogl

Abstract

Tubulobulbar complexes (TBCs) are actin-related double-membrane invaginations formed at intercellular junctions in the seminiferous epithelium of mammalian testis. They occur at basal junction complexes between neighboring Sertoli cells and at apical junctions between Sertoli cells and spermatids. They are proposed to internalize intercellular junctions during the translocation of spermatocytes from basal to adluminal compartments of the seminiferous epithelium, and during sperm release from Sertoli cells. Although TBCs are specific to the seminiferous epithelium, they morphologically resemble podosomes in osteoclasts. Previously, we have reported that a key group of proteins consisting of N-WASp, Arp2/3, cortactin and dynamin that occur at podosomes also is present at TBCs. Here we explore the prediction that zyxin, a focal adhesion protein known to be present at podosomes, also is present at apical TBCs. A rabbit polyclonal anti-zyxin antibody (B71) was used to label fixed fragments and frozen sections of testis. In both fragments and sections, B71 labeled tubular regions of TBCs at apical sites of attachment between Sertoli cells and spermatids, in addition to being localized at actin related intercellular adhesion junctions...Continue Reading

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Citations

May 15, 2013·Asian Journal of Andrology·Xiaojing QianC Yan Cheng
Jan 5, 2013·Human Reproduction Update·Xiang XiaoC Yan Cheng
May 21, 2013·Spermatogenesis·Xiaojing QianC Yan Cheng
Dec 16, 2016·Biochimica Et Biophysica Acta. Molecular Cell Research·Katarzyna ChojnackaDolores D Mruk
Oct 13, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Arlo AdamsA Wayne Vogl
Jul 25, 2013·American Journal of Physiology. Endocrinology and Metabolism·Hin-Ting WanC Yan Cheng
Oct 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elissa W P WongC Yan Cheng
Jun 5, 2018·Reproduction, Fertility, and Development·A KumarN H Balasinor
Sep 20, 2017·Seminars in Cell & Developmental Biology·Haiqi ChenC Yan Cheng

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