Focal adhesions, contractility, and signaling

Annual Review of Cell and Developmental Biology
K Burridge, M Chrzanowska-Wodnicka

Abstract

Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provided a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control. The assembly of focal adhesions is regulated by the GTP-binding protein Rho. Rho stimulates contractility which, in cells that are tightly adherent to the substrate, generates isometric tension. In turn, this leads to the bundling of actin filaments and the aggregation of integrins (extracellular matrix receptors) in the plane of the membrane. The aggregation of integrins activates the focal adhesion kinase and leads to the assembly of a multicomponent signaling complex.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J R Feramisco
Mar 15, 1979·Experimental Cell Research·S H ZigmondJ Bryan
Dec 1, 1975·Journal of Cellular Physiology·H Otsuka, M Moskowitz
May 1, 1976·The Journal of Cell Biology·G Albrecht-Buehler
Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·L H RomerC E Turner
Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·B GeigerA Ben-Ze'ev
Apr 1, 1992·The Journal of Cell Biology·S E LaFlammeK M Yamada
Oct 1, 1992·The Journal of Cell Biology·J L Rodríguez FernándezA Ben-Ze'ev
Sep 20, 1992·Journal of Molecular Biology·C WeigtH E Meyer
Dec 1, 1992·The Journal of Cell Biology·I SadlerM C Beckerle
Jan 1, 1992·Annual Review of Biochemistry·J L TanJ A Spudich
Sep 10, 1992·Nature·J SettlemanR A Weinberg
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S K HanksS K Patel
Mar 1, 1992·The Journal of Cell Biology·A W CrawfordM C Beckerle
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D SchallerJ T Parsons
Apr 1, 1991·Journal of Muscle Research and Cell Motility·G Isenberg
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M A SchwartzD E Ingber
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T KitazawaA P Somlyo
Aug 1, 1991·Experimental Cell Research·M A SchwartzC Lechene
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J KornbergR L Juliano
Feb 1, 1991·Current Opinion in Cell Biology·J R Sellers

❮ Previous
Next ❯

Citations

Dec 19, 1998·Microscopy Research and Technique·A WellsH Shiraha
Dec 19, 1998·Microscopy Research and Technique·J A Greenwood, J E Murphy-Ullrich
Dec 19, 1998·Microscopy Research and Technique·M BaillyJ E Segall
Oct 3, 1999·Microscopy Research and Technique·I SpectorM R Bubb
Sep 23, 1998·Cell Motility and the Cytoskeleton·I H GelmanX Lin
Dec 3, 1999·Journal of Neuroscience Research·J LilienJ Balsamo
Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J L Rodríguez-Fernández
Oct 31, 2000·Microscopy Research and Technique·J StutzmannP Simon-Assmann
Jun 28, 2001·Journal of Biomedical Materials Research·K WebbP A Tresco
Mar 29, 2001·Cell Motility and the Cytoskeleton·O J PletjushkinaK A Jacobson
Feb 9, 2002·Journal of Cellular Biochemistry·Melissa Coon, Roman Herrera
Jan 25, 2002·Journal of Cellular Physiology·Ratna K VadlamudiRakesh Kumar
Sep 27, 2001·Journal of Cellular Physiology·E H Danen, K M Yamada
Dec 22, 1999·Journal of Structural Biology·K A Taylor, D W Taylor
Jul 21, 2010·Analytical and Bioanalytical Chemistry·Jeng-Hao PaiNancy L Allbritton
Nov 4, 2005·Histochemistry and Cell Biology·Annette B GallerMatthias Reinhard
Dec 7, 2007·Pflügers Archiv : European journal of physiology·Thomas LudwigUlrich S Schwarz
Nov 19, 2009·Cell and Tissue Research·Samuel Schmidt, Peter Friedl
Jan 5, 2007·Biomechanics and Modeling in Mechanobiology·James H-C Wang, Jeen-Shang Lin
Jul 10, 2012·Biomechanics and Modeling in Mechanobiology·Sean P SheehyKevin Kit Parker
Mar 10, 2006·Annals of Biomedical Engineering·Nathan J SniadeckiChristopher S Chen
Sep 24, 2010·Biomedical Microdevices·Hojeong JeonCostas P Grigoropoulos
Jan 21, 2009·Cancer Metastasis Reviews·Sanjay Kumar, Valerie M Weaver

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM29860

Methods Mentioned

BETA
electron microscopy
motility assays
GTPase
exotransferase
nucleotide exchange
two-hybrid
transfection
antisense oligonucleotides

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Actin-binding Proteins

Actin-binding proteins are a component of the actin cytoskeleton that play essential roles in cellular functions such as regulation of actin polymerization, maintenance of cell polarity, gene expression regulation, cell motility and many more functions. Discover the latest research on actin-binding proteins here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Annual Review of Cell and Developmental Biology
B M JockuschJ Winkler
Annual Review of Cell and Developmental Biology
Martin A SchwartzMark H Ginsberg
Current Opinion in Cell Biology
S M Schoenwaelder, K Burridge
© 2021 Meta ULC. All rights reserved