Focal cartilage defect compromises fluid-pressure dependent load support in the knee joint

International Journal for Numerical Methods in Biomedical Engineering
Y Dabiri, LePing Li

Abstract

A focal cartilage defect involves tissue loss or rupture. Altered mechanics in the affected joint may play an essential role in the onset and progression of osteoarthritis. The objective of the present study was to determine the compromised load support in the human knee joint during defect progression from the cartilage surface to the cartilage-bone interface. Ten normal and defect cases were simulated with a previously tested 3D finite element model of the knee. The focal defects were considered in both condyles within high load-bearing regions. Fluid pressurization, anisotropic fibril-reinforcement, and depth-dependent mechanical properties were considered for the articular cartilages and menisci. The results showed that a small cartilage defect could cause 25% reduction in the load support of the knee joint due to a reduced capacity of fluid pressurization in the defect cartilage. A partial-thickness defect could cause a fluid pressure decrease or increase in the remaining underlying cartilage depending on the defect depth. A cartilage defect also increased the shear strain at the cartilage-bone interface, which was more significant with a full-thickness defect. The effect of cartilage defect on the fluid pressurization als...Continue Reading

References

Feb 1, 1976·The Journal of Bone and Joint Surgery. British Volume·C A McDevitt, H Muir
Aug 1, 1979·Annals of the Rheumatic Diseases·B B SeedholmV Wright
Nov 11, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M J VenerT R Oegema
May 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K A AthanasiouV C Mow
Jul 1, 1989·The American Journal of Sports Medicine·F R Noyes, C L Stabler
Nov 1, 1968·Annals of the Rheumatic Diseases·P S WalkerV Wright
Jan 1, 1984·Journal of Biomechanics·V C MowW M Lai
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F GuilakV C Mow
Aug 15, 1998·Arthritis and Rheumatism·D T Felson, Y Zhang
Jun 19, 2001·Journal of Biomechanics·K R KaufmanK N An
Sep 5, 2002·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Karin HjelleMats Brittberg
Mar 18, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·T T PhamM Soubrier
May 2, 2003·The Journal of Bone and Joint Surgery. American Volume·Mats Brittberg, Carl S Winalski
Sep 25, 2003·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Reha N TandoganAziz Alturfan
Nov 8, 2003·Rheumatic Diseases Clinics of North America·David B Burr, Eric L Radin
Apr 21, 2004·Annals of Biomedical Engineering·Thomas P AndriacchiSeungbum Koo
Oct 30, 2004·Computer Methods in Biomechanics and Biomedical Engineering·Samer M AdeebNigel G Shrive
Feb 17, 2005·Journal of Biomechanics·Georg N DudaHermann Bail
Jul 5, 2005·Clinical Orthopaedics and Related Research·Gerard A Ateshian, Clark T Hung
Jun 27, 2006·Computers in Biology and Medicine·Estefanía PeñaManuel Doblaré
Jan 1, 2009·Cartilage·Won C BaeRobert L Sah
Jul 26, 2011·Journal of the Mechanical Behavior of Biomedical Materials·M KazemiM D Buschmann
Aug 4, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Ali Vahdati, Diane R Wagner
Nov 11, 2011·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·L P Li, K B Gu
Feb 21, 2013·Computational and Mathematical Methods in Medicine·Y Dabiri, L P Li
Mar 19, 2013·Medical Engineering & Physics·Hongqiang GuoRobert L Spilker
Mar 20, 2013·Computational and Mathematical Methods in Medicine·M KazemiL P Li

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Citations

Nov 30, 2016·Scientific Reports·Mikko S VenäläinenRami K Korhonen
Jun 27, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley HeuijerjansCorrinus C van Donkelaar
Mar 7, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Katariina A H MyllerMikko S Venäläinen
Jun 16, 2019·Journal of Biomechanical Engineering·Benjamin C MarchiRhima M Coleman
May 31, 2017·Microscopy Research and Technique·Yulin LinChuanbin Mao
Aug 25, 2020·Cartilage·Wenqiang YanDongquan Shi
Nov 28, 2017·Biomechanics and Modeling in Mechanobiology·Petri TanskaRami K Korhonen
Dec 29, 2020·Osteoarthritis and Cartilage·J K SarinJ Töyräs
Sep 19, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Margot S FarnhamChristopher Price

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