PMID: 69017Apr 1, 1977

Focal chemotherapy of brain tumours using semipermeable membranes

Journal of Neurology, Neurosurgery, and Psychiatry
H A WilkinsonS Weems


Semipermeable silastic rubber membranes can be used to diffuse focally a variety of chemicals including antitumour drugs. Of the eight drugs tested, in vitro tests showed the best diffusion with dactinomycin, mithramycin, and oncovin, and the poorest diffusion with bleomycin, fluorouracil, and thiotepa. Biological testing was performed with mithramycin, dactinomycin, and oncovin using tissue cultures of human glioblastoma and subcutaneous implants of mouse ependymoblastoma. All three drugs caused rapid tissue culture cell death with direct injection, and impeded tumour growth when given intraperitoneally. Dactinomycin by silastic diffusion proved more effective than mithramycin against tissue cultures, but neither drug had a significant effect against local tumours treated with implanted drug capsules. Silastic diffusion of oncovin reduced tumour sizes significantly ipsilateral to the implant, compared to contralateral implants and to untreated controls.


Oct 30, 1972·JAMA : the Journal of the American Medical Association·D FewerM R Powell
May 1, 1973·Anesthesiology·H A WilkinsonP Patel
Feb 1, 1969·Journal of Neurosurgery·V H MarkW Sweet
Jun 1, 1968·Transactions of the New York Academy of Sciences·J Folkman, V H Mark
May 1, 1969·Cancer·C Wilson, H Norrell
Jan 1, 1971·Experimental Neurology·H A WilkinsonR Wilson
May 1, 1968·Anesthesiology·J FolkmanT Moghul
Jul 3, 1967·JAMA : the Journal of the American Medical Association·H Norrell, C Wilson


Feb 1, 1991·Journal of Neuro-oncology·T Tomita
Dec 1, 1995·Neurosurgery·K A WalterH Brem
Mar 24, 2012·Neurosurgery Clinics of North America·Seema Nagpal
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·P Sampath, H Brem

Related Concepts

Antineoplastic Agents
Brain Tumor, Recurrent
Papillary Ependymoma
5-FU medac
Mixed Gliomas
Membranes, Artificial
Study, Methodological

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