Focal cooling of brain parenchyma in a transient large vessel occlusion model: proof-of-concept

Journal of Neurointerventional Surgery
Jildaz CaroffMatthew J Gounis

Abstract

The neuroprotective benefit of therapeutic hypothermia (TH) has been demonstrated, but systemic side effects and time required to achieve effective TH in acute ischemic stroke (AIS) care limits clinical use. We investigate rapid and localized cooling using a novel insulated catheter in an ischemia-reperfusion model. In phase I (n=4), cold saline was delivered to the canine internal carotid artery via an insulated catheter. Temperature was measured using intracerebral thermocouples. The coolant flow rate was varied to meet a target temperature of 31-32°C in the hemisphere infused. In phase II (n=8), a temporary middle cerebral artery occlusion was created. Five dogs underwent localized TH at the optimal flow rate from phase I, and the remaining animals were untreated controls. Cooling was initiated 5 min before recanalization and continued for an additional 20 min following 45 min of occlusion duration. The outcome was infarct volume and neurological function. Ipsilateral tissue cooling rates were 2.2±2.5°C/min at a flow rate of 20-40 mL/min with an observed minimum of 23.8°C. Tissue cooling was localized to the ipsilateral side of the infusion with little impact on temperatures of the core or contralateral hemisphere of the bra...Continue Reading

References

May 5, 2007·Brain : a Journal of Neurology·H Bart van der WorpMalcolm R Macleod
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cameron RinkChandan K Sen
Aug 21, 2010·Stroke; a Journal of Cerebral Circulation·Thomas M HemmenUNKNOWN ICTuS-L Investigators
Dec 15, 2010·Journal of Neurosurgical Anesthesiology·Arthur E SchwartzLinda Mongero
Feb 23, 2012·Nature Reviews. Neuroscience·Midori A Yenari, Hyung Soo Han
Feb 19, 2013·Lancet Neurology·Tzu-Ching Wu, James C Grotta
Jun 5, 2013·Stroke; a Journal of Cerebral Circulation·Matthew J GounisJu-Yu Chueh
Jan 18, 2014·Stroke; a Journal of Cerebral Circulation·Katja PiironenMarkku Kaste
Feb 13, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Elga EspositoSven Poli
May 16, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·H Bart van der WorpUNKNOWN EuroHYP-1 investigators
Feb 14, 2015·Journal of Neurointerventional Surgery·Thomas K MattinglyStephen P Lownie
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Charudatt VaityMaurizio Cecconi
Jun 13, 2015·Lancet Neurology·Marc Fisher, Jeffrey L Saver
Mar 5, 2016·Journal of Neurointerventional Surgery·Yang-Ha HwangDavid S Liebeskind
May 21, 2016·Stroke; a Journal of Cerebral Circulation·Jian ChenXunming Ji
May 26, 2016·Translational Stroke Research·Italo Linfante, Marilyn J Cipolla
Jun 18, 2016·Medical Engineering & Physics·Thomas L MerrillDenise R Merrill
Nov 12, 2016·Stroke; a Journal of Cerebral Circulation·Patrick LydenUNKNOWN Collaborators
Nov 20, 2016·AJNR. American Journal of Neuroradiology·G A ChristoforidisT J Carroll
Nov 20, 2016·Stroke; a Journal of Cerebral Circulation·Marjolein GeurtsH Bart van der Worp
May 4, 2017·Progress in Cardiovascular Diseases·Rajan A G Patel, Paul W McMullen
May 11, 2017·Stroke; a Journal of Cerebral Circulation·Michael Tymianski
Aug 24, 2017·Neuropharmacology·Kota Kurisu, Midori A Yenari
Apr 20, 2018·Stroke; a Journal of Cerebral Circulation·Patrick Lyden
Jul 19, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chuanjie WuXunming Ji
Nov 22, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick D LydenPadmesh S Rajput
Jan 28, 2020·European Stroke Journal·H Bart van der WorpUNKNOWN EuroHYP-1 investigators

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Citations

Jan 18, 2020·Brain Circulation·Bridget C VaughanRobert D Schultz
Jan 18, 2020·Brain Circulation·Thomas L MerrillAngelos A Konstas
Dec 8, 2020·Frontiers in Neurology·Jae H ChoiJohn Pile-Spellman
Feb 4, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yun HanYuchuan Ding
Jun 24, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Giorgio Fm CattaneoStephan Meckel

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