Focal cryosurgery followed by penile rehabilitation as primary treatment for localized prostate cancer: initial results

Urology
David S EllisJohn C Rewcastle

Abstract

The study reported here was undertaken to assess medium short-term efficacy of focal cryoablation as primary therapy for localized prostate cancer and to determine the rate of morbidity in patients who undergo this treatment. Patients were treated with focal cryoablation with argon cryoprobes under ultrasonographic visualization with temperature monitoring. Men who were potent at the time of intervention were encouraged to use a vacuum erectile dysfunction device on a regular basis after treatment. Incontinence was defined as any urine leakage regardless of the number of pads worn (if any). Potency was defined as the ability to achieve an erection sufficient to complete intercourse with or without oral pharmaceuticals. Biochemical failure was defined as 3 successive rises in serum prostate-specific antigen (PSA) concentration. A total of 60 consecutive patients were treated. Mean patient age was 69.0 years; mean PSA was 7.2 ng/mL, median Gleason score was 6, and median stage was T1c. Before treatment was initiated, all patients were continent and 72.7% were potent. Mean follow-up for the entire population was 15.2+/-7.4 months. Of those patients who were continent before receiving treatment, 3.6% were incontinent at 6 months, b...Continue Reading

References

Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Michael J ZelefskySteven A Leibel
Sep 13, 2002·The New England Journal of Medicine·Gunnar SteineckUNKNOWN Scandinavian Prostatic Cancer Group Study Number 4
Sep 17, 2004·International Urology and Nephrology·Felipe ReisEmerson Zani
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Donald BrabbinsJohn Wong
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Steven J FeigenbergHoward Sandler
Sep 27, 2006·Journal of Endourology·Duke K BahnJohn C Rewcastle
Nov 15, 2006·Anti-cancer Agents in Medicinal Chemistry·Ferruccio De LorenzoMyroslava Tymoshchuk

❮ Previous
Next ❯

Citations

May 14, 2014·Nature Reviews. Clinical Oncology·Laurence Klotz, Mark Emberton
Dec 24, 2010·Critical Reviews in Biomedical Engineering·Christopher L Brace
Oct 5, 2011·Therapeutic Advances in Urology·Michael S BorofskySamir S Taneja
Jan 15, 2013·BMC Urology·Zachary HaleCharles J Rosser
Nov 24, 2011·Prostate Cancer·Luigi Mearini, Massimo Porena
Feb 12, 2010·Future Oncology·Hashim U Ahmed, Mark Emberton
Apr 18, 2009·Current Urology Reports·Chad R Ritch, Aaron E Katz
Apr 29, 2010·Current Urology Reports·Matvey Tsivian, Thomas J Polascik
Mar 25, 2011·Current Urology Reports·Christian G Chaussy, Stefan F Thüroff
Feb 3, 2012·Current Urology Reports·Michael R AbernThomas J Polascik
May 7, 2010·Journal of Endourology·Emilie LecornetMark Emberton
May 7, 2010·Journal of Endourology·Vladimir MouravievThomas J Polascik
May 19, 2010·Journal of Endourology·Uri LindnerJohn Trachtenberg
Jun 12, 2009·International Journal of Impotence Research·J M MayesT J Polascik
Aug 16, 2008·World Journal of Urology·Hashim Uddin Ahmed, Mark Emberton
Oct 22, 2010·World Journal of Urology·U LindnerJ Trachtenberg
Jul 17, 2012·Urologic Oncology·G BozziniN Betrouni
Sep 8, 2010·Urologic Oncology·Emilie LecornetMark Emberton
Aug 18, 2009·The Journal of Urology·U LindnerJ Trachtenberg
Oct 30, 2009·International Journal of Radiation Oncology, Biology, Physics·Hendrik IsbarnMarkus Graefen
Jan 4, 2012·Histopathology·John R SrigleyAndrew J Evans
Feb 13, 2010·BJU International·David LevyJ Stephen Jones
Nov 13, 2014·World Journal of Urology·Ghassan A BarayanSimon Tanguay
Jul 4, 2015·Health Technology Assessment : HTA·Craig R RamsayThomas B Lam
Jul 15, 2015·Prostate International·Susan Marshall, Samir Taneja
Jun 19, 2013·European Urology·Massimo ValerioThomas J Polascik
Jun 14, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·V KasivisvanathanH U Ahmed
Mar 26, 2015·Polish journal of radiology·Mohammed AlkhorayefMaram A Fagiri
Mar 20, 2014·The Journal of Urology·Al B BarqawiE David Crawford
Jun 15, 2016·JMIR Research Protocols·Ana Fernandez OtsKomiti Ese Enari
Sep 7, 2016·European Urology·Massimo ValerioMark Emberton
Nov 1, 2016·Nature Reviews. Urology·Marlon PereraNathan Lawrentschuk
Sep 22, 2012·AJR. American Journal of Roentgenology·Joyce G R BomersJurgen J Fütterer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.