Focal Hypoperfusion in Acute Ischemic Stroke Perfusion CT: Clinical and Radiologic Predictors and Accuracy for Infarct Prediction

AJNR. American Journal of Neuroradiology
O BillP Michel

Abstract

Perfusion CT may improve the diagnostic performance of noncontrast CT in acute ischemic stroke. We assessed predictors of focal hypoperfusion in acute ischemic stroke and perfusion CT performance in predicting infarction on follow-up imaging. Patients from the Acute STroke Registry and Analysis of Lausanne data base with acute ischemic stroke and perfusion CT were included. Clinical and radiologic data were collected. We identified predictors of focal hypoperfusion using multivariate analyses. From the 2216 patients with perfusion CT, 38.2% had an acute ischemic lesion on NCCT and 73.3% had focal hypoperfusion on perfusion CT. After we analyzed 104 covariates, high-admission NIHSS, visual field defect, aphasia, hemineglect, sensory deficits, and impaired consciousness were positively associated with focal hypoperfusion. Negative associations were pure posterior circulation, lacunar strokes, and anticoagulation. After integrating radiologic variables into the multivariate analyses, we found that visual field defect, sensory deficits, hemineglect, early ischemic changes on NCCT, anterior circulation, cardioembolic etiology, and arterial occlusion were positively associated with focal hypoperfusion, whereas increasing onset-to-CT ...Continue Reading

References

Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Sep 6, 2001·Stroke; a Journal of Cerebral Circulation·C A MolinaJ Alvarez-Sabín
Sep 12, 2003·The New England Journal of Medicine·Elaine M HylekDaniel E Singer
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellJeffrey L Saver
Aug 16, 2008·Stroke; a Journal of Cerebral Circulation·Mei Yong, Markku Kaste
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Mark W Parsons
Oct 22, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Enrique Marco de LucasFernando Quintana
Jun 5, 2010·Stroke; a Journal of Cerebral Circulation·Jeffrey L SaverUNKNOWN GWTG-Stroke Steering Committee and Investigators
Jul 29, 2011·Annals of Neurology·Krishna A DaniUNKNOWN Translational Medicine Research Collaboration Multicentre Acute Stroke Imaging Study
Feb 28, 2013·Stroke; a Journal of Cerebral Circulation·Sanne M ZinkstokPaul J Nederkoorn
Mar 7, 2013·Stroke; a Journal of Cerebral Circulation·Guangming ZhuMax Wintermark
Jun 20, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Lars-Peder PallesenUNKNOWN BASICS Study Group
Sep 26, 2014·Neuroradiology·Amanda MurphyRichard I Aviv
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Feb 24, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Wenjie CaoBruce C V Campbell
Nov 2, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O BillP Michel

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
L-P PallesenP Michel
Journal of Applied Physiology
Dirk J Duncker, Daphne Merkus
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Salvatore RudilossoXabier Urra
© 2022 Meta ULC. All rights reserved