Focal Laser Ablation of Prostate Cancer: Results in 120 Patients with Low- to Intermediate-Risk Disease.

Journal of Vascular and Interventional Radiology : JVIR
Eric WalserStephen B Williams

Abstract

Can focal laser ablation (FLA) of low to intermediate risk prostate cancer preserve sexual and urinary function with low morbidity while providing adequate oncologic outcomes. Transrectal FLA was done in 120 patients with low- to intermediate-risk prostate cancer. MR imaging thermometry controlled ablation. At 6 and 12 months, patients had clinical and MR imaging follow-up with biopsy of suspicious areas. Patients submitted surveys of sexual and urinary function. Multivariate logistic regression identified determinants of positive imaging and biopsies. Two-sided Wilcoxon signed rank test evaluated scores and laboratory values. Median patient age was 64 years, and median prostate-specific antigen (PSA) was 6.05 ng/mL. Median follow-up period was 34 months (range, 17-55 months). Gleason score was 3+3=6 in 37 (30.8%), 3+4=7 in 56 (46.7%), and 4+3=7 in 27 (22.5%) patients. Tumor stage was T1c in 89 (74.2%), T2a in 26 (21.7%), and T2b in 5 (4.2%) patients. Twenty (17%) patients had additional oncologic therapy 1 year after FLA when biopsy confirmed cancer following abnormal MR imaging. There was no difference between functional scores before and after ablation. Median PSA decreased to 3.25 at 12 months (P < .001). Tumor diameter abo...Continue Reading

Citations

Nov 15, 2019·Current Opinion in Urology·Dmitry EnikeevPetr Glybochko
Nov 27, 2019·Photochemistry and Photobiology·Brian C Wilson, Robert A Weersink
Jan 25, 2020·Investigative Radiology·Junichi TokudaEhud J Schmidt
May 24, 2020·World Journal of Urology·Rafael R Tourinho-BarbosaThomas J Polascik
Nov 21, 2020·Journal of Magnetic Resonance Imaging : JMRI·James BlackwellNiall Colgan
Jun 7, 2021·Urology·Brian Chao, Herbert Lepor
Jul 30, 2021·The British Journal of Radiology·Mark PaxtonSangeet Ghai
Nov 2, 2021·The British Journal of Radiology·Annemarijke van LuijtelaarJoyce Gr Bomers

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