Focal mechanisms underlying ventricular tachycardia during prolonged ischemic cardiomyopathy

Circulation
Steven M Pogwizd

Abstract

The present study was performed to define the mechanisms underlying spontaneously occurring ventricular arrhythmias in the failing heart. Three-dimensional cardiac mapping from as many as 232 intramural sites was performed in five dogs with ischemic cardiomyopathy induced by multiple intracoronary embolizations. After 5 to 10 weekly embolizations with 90-microns latex microspheres into the left anterior and circumflex coronary arteries, left ventricular ejection fraction decreased from 63 +/- 3% to 22 +/- 3%. Subsequent weekly Holter monitoring of dogs in the conscious state demonstrated frequent multiform premature ventricular complexes (PVCs) (< or = 2000/d), couplets, and runs of ventricular tachycardia (VT) (< or = 70 beats in duration and < or = 560 beats per minute) in all dogs. Three-dimensional mapping of spontaneous rhythm for 60 minutes was performed an average of 6.4 weeks after the last embolization, during which time each dog demonstrated multiform PVCs, couplets, and runs of nonsustained VT at rates comparable to those in the conscious state. Mapping was of sufficient density to define the mechanism for 31 PVCs, 45 beats of ventricular couplets, and 99 beats of VT. Sinus beats preceding PVCs (n = 36) initiated in ...Continue Reading

References

Oct 1, 1991·American Heart Journal·M I Anastasiou-NanaJ W Mason
Feb 15, 1991·The American Journal of Cardiology·K V OlshausenJ Meyer
Jul 1, 1990·Progress in Cardiovascular Diseases·P Anversa, E H Sonnenblick
Mar 1, 1987·Pacing and Clinical Electrophysiology : PACE·R E IdekerF R Bartram
Aug 10, 1989·The New England Journal of Medicine·UNKNOWN Cardiac Arrhythmia Suppression Trial (CAST) Investigators
Sep 24, 1987·The New England Journal of Medicine·J M McLenachanH J Dargie
Apr 1, 1985·Cardiovascular Research·H J Smith, A Nuttall
Jul 1, 1966·The American Journal of Cardiology·H T DodgeR R Hawley
Sep 1, 1983·Journal of the American College of Cardiology·J S CameronA L Bassett
Jan 1, 1983·The American Journal of Cardiology·R F GilmourD P Zipes

❮ Previous
Next ❯

Citations

Jul 5, 2008·Pflügers Archiv : European journal of physiology·Sandeep S HothiChristopher L-H Huang
May 29, 2010·Journal of Cardiovascular Pharmacology·Mithilesh K Das, Douglas P Zipes
Feb 1, 1997·Pacing and Clinical Electrophysiology : PACE·N KanaanA Kadish
Oct 11, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Chengzong HanBin He
Apr 3, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Elizabeth M CherryRobert F Gilmour
Apr 2, 2011·Future Cardiology·Saurabh Malhotra, Mithilesh K Das
Nov 30, 2013·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·T Jared Bunch, Jeffrey L Anderson
Nov 4, 2000·Journal of Cardiovascular Electrophysiology·R CoronelJ M de Bakker
Mar 25, 1998·Journal of Cardiovascular Electrophysiology·J T Vermeulen
Jun 20, 1998·AACN Clinical Issues·C C Ballew, J Reigle
Feb 23, 2013·Basic Research in Cardiology·Yukiomi TsujiDobromir Dobrev
Jun 19, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Chengzong HanBin He
Oct 6, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Sara PartemiJosep Brugada
Mar 29, 2011·Heart Failure Clinics·Peem LorvidhayaAlfred E Buxton
Mar 15, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Chengzong HanBin He
Feb 2, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mithilesh K DasJohn M Miller
Nov 3, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Renee M Sullivan, Brian Olshansky
Dec 20, 2011·Journal of Cardiovascular Electrophysiology·Carolyn M Johnson, Steven M Pogwizd
Aug 16, 2000·IEEE Transactions on Bio-medical Engineering·A R BarnetteW M Smith
Jun 13, 2000·Cardiology Clinics·A E BuxtonV Torres
Mar 29, 2005·Angiology·Yusuf AtmacaDervis Oral
May 24, 2013·Clinical Medicine Insights. Cardiology·Mazen T GhanemJohn K Zarif
May 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·D Kelly, R Arora
Sep 25, 2014·Molecular Imaging·Sanne de JongMarc A M J van Zandvoort
Sep 3, 2003·Journal of Cardiovascular Electrophysiology·Cesar Alberte, Douglas P Zipes
Aug 22, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Xian-Sheng LiuGea-Ny Tseng
Nov 23, 2006·Physiology·Donald M Bers
Dec 26, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Rodolphe P KatraKenneth R Laurita
Nov 25, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Chengzong HanBin He

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.