Focal myositis: New insights on diagnosis and pathology

Neurology
Laure GallayNathalie Streichenberger

Abstract

To better define in a cohort study the clinical and pathologic features of focal myositis (FM). With the use of the usual clinicopathologic definition, each confirmed case of FM in the Lyon University Hospital's myopathologic database between 2000 and 2016 was retrieved. Clinical, pathologic, imaging, serologic, and therapeutic data were collected. When data were missing but feasible, appropriate pathologic analyses were performed. Of the 924 patients included in the database, 37 (4%) had confirmed FM (14 female, 23 male patients). The main symptoms were pain (n = 30, 81%), muscular mass (n = 16, 43%), erythema at the site of FM (n = 12, 32%), and fever (n = 9, 24%). Serum creatine kinase was normal in most patients (81%); serum immune abnormalities were frequent (inflammatory syndrome in sera [39%], dysglobulinemia [52%], and anti-nuclear antibody positivity [29%]). In addition to confirming previously reported findings, pathologic analyses found significant rates of vasculitis (68%) and fasciitis (73%). Here, FM appeared frequently to be associated with other diseases such as immune-mediated inflammatory disease (IMID; 32%), neoplasia (24%), and radiculopathy (11%). Regarding outcomes, 64% of the cases had received immunosupp...Continue Reading

References

Jul 1, 1977·Cancer·R R HeffnerK M Earle
Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Sep 1, 1992·Arquivos de neuro-psiquiatria·O J NascimentoA Q Araújo
Sep 1, 1992·Clinical Rheumatology·J E NaschitzJ H Boss
Apr 1, 1981·Arthritis and Rheumatism·H YaziciS Yurdakul
Jul 1, 1981·Archives of Neurology·R R Heffner, S A Barron
Dec 1, 1993·British Journal of Rheumatology·M NaughtonB D Williams
Mar 15, 1997·BMJ : British Medical Journal·T M LawsonB D Williams
Sep 26, 2000·Muscle & Nerve·A G SmithJ W Russell
Nov 14, 2002·Annals of the Rheumatic Diseases·S GallienL Guillevin
Feb 26, 2004·Muscle & Nerve·Nathalie StreichenbergerPhilippe Petiot
Nov 18, 2004·Journal of the Neurological Sciences·Kenji SekiguchiKazuo Chihara
Dec 25, 2007·International Journal of Cardiology·Patrick AsbachEckart Fleck
Mar 4, 2009·Skeletal Radiology·Michele GaetaAlfredo Blandino
Apr 14, 2009·The American Journal of Surgical Pathology·Aaron AuerbachElisabeth J Rushing
May 22, 2009·AJR. American Journal of Roentgenology·Maximilian SchulzeMarius Horger
May 26, 2010·Acta Neurologica Scandinavica·A JainR Handa
Jan 15, 2011·European Journal of Radiology·M WagnerR Schmitt
Dec 14, 2011·Neuromuscular Disorders : NMD·Hanne Marie Bøe LundeLaurence A Bindoff
Jan 25, 2012·Rheumatology·Richard ConwayRobert J Coughlan
Sep 17, 2013·Muscle & Nerve·Teerin LiewluckJennifer A Tracy
Jul 1, 2014·Arthritis & Rheumatology·Isabelle MarieAnne-Laure Bedat-Millet
Jul 1, 2014·Neurology·Thomas E LloydSteven A Greenberg
Jul 23, 2015·Brain : a Journal of Neurology·Lénaig Mescam-ManciniOlivier Benveniste
Dec 3, 2015·Clinical Rheumatology·Susana RoveranoSergio Paira
Dec 29, 2015·Expert Review of Clinical Pharmacology·Serena FasanoDavid A Isenberg
Jan 19, 2016·Clinical Reviews in Allergy & Immunology·Angela CeribelliCarlo Selmi
Mar 15, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Cord SunderkötterHeinz Wiendl
Apr 22, 2016·Journal of Internal Medicine·C V Oddis
Oct 30, 2016·Neuromuscular Disorders : NMD·P DevicP Petiot

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Citations

Dec 19, 2018·Clinical Nuclear Medicine·Aisheng DongYang Wang
Jul 12, 2019·Internal Medicine Journal·Jianna He, Allan Sturgess
Aug 3, 2019·Journal of Clinical Pathology·Gaetano VattemiGiuliano Tomelleri
Jul 22, 2021·Rheumatology·Ana Bento da SilvaMaria João Gonçalves
Jul 10, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Lawrence Ledoux-HutchinsonPhilippe Major

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