PMID: 3762186Oct 1, 1986Paper

Focal nodular hyperplasia and hepatic adenoma: a review of eight cases in the pediatric age group

Journal of Surgical Oncology
E E Lack, K Ornvold

Abstract

A review of all primary hepatic tumors seen at Children's Hospital, Boston over a 57-year period disclosed six cases of focal nodular hyperplasia (FNH) and two hepatic adenomas (HA). The children with FNH (four females, two males) ranged in age from 6 months to 15 years (average age: 7 years). Three patients had "hepatomegaly" noted on physical examination 2 months to 2 or more years prior to diagnosis. The average diameter of FNH was 7.3 cm (range 2.5-10 cm). The lesion was confined to the right lobe in four cases and showed bilobar involvement in two. The HA's were diagnosed in a newborn male and a 2-year-old girl, both of whom were symptomatic because of large tumor size (10 cm each). There was no maternal history of exposure to exogenous steroids during pregnancy. Three children with FNH underwent hepatic lobectomy and were alive and well 4 to 17 years later. One child who died of acute leukemia had an incidental FNH discovered at autopsy. Two patients were treated conservatively with biopsy only and were alive and symptom-free 13 and 15 years later. Both children with HA underwent hepatic lobectomy. One died postoperatively because of intra-abdominal hemorrhage and the other was alive and well 10 1/2 years later. Complete ...Continue Reading

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Citations

Jan 1, 1988·Archives of Gynecology and Obstetrics·Z J HagayA Witznitzer
Feb 11, 2004·American Journal of Surgery·Joseph KimDouglas W Hanto
Jun 9, 2001·Journal of Pediatric Gastroenterology and Nutrition·R SomechS Rief
Feb 17, 2006·Journal of Pediatric Surgery·Giuseppe De LucaAntonio Martone
Nov 1, 1995·Journal of Pediatric Surgery·D ReymondH P Wagner
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adrian Reuben
Sep 3, 2017·Journal of Gastrointestinal Cancer·Hemant Kumar SinghMahesh Goel
Jan 1, 1993·Medical and Pediatric Oncology·D ReymondA Zimmermann
Aug 1, 2015·World Journal of Gastroenterology : WJG·Liliana ChioreanChristoph F Dietrich

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