Focal oxidant and Ras signaling on the ER surface activates autophagy.

Autophagy
Ru Feng Wu, Lance S Terada

Abstract

Eukaryotic cells react to a variety of intrinsic and extrinsic stresses with patterned responses, each triggered within relevant subcellular domains. One feature common to a variety of cellular stresses is the production of reactive oxidant species (ROS), suggesting an additional element of oxidative stress. We addressed the role of oxidants in ER stress and find instead that localized production of ROS by the ER mediates protective signaling, leading to, among other things, Ras-dependent activation of autophagy. Thus, focal oxidant production is incorporated into stress response pathways, in this case participating in homeostatic signaling circuits on the ER surface.

References

May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·A AlbiniB Ensoli
Sep 8, 1995·The Journal of Biological Chemistry·H M LanderA Novogrodsky
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S C FloresJ M McCord
Jun 20, 1997·The Journal of Biological Chemistry·A K BhuniaS Chatterjee
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·H XiaoK T Jeang
Jan 10, 2001·The American Journal of the Medical Sciences·L S TeradaS C Flores
May 4, 2002·Nature Cell Biology·Vi K ChiuMark R Philips
May 5, 2004·The Journal of Biological Chemistry·Takeshi AdachiRichard A Cohen
May 5, 2004·The Journal of Cell Biology·Junichi HitomiMasaya Tohyama
Aug 7, 2004·Developmental Cell·Ryan C ScottThomas P Neufeld
Sep 8, 2004·Molecular Cell·Cole M HaynesAntony A Cooper
Feb 12, 2005·Antioxidants & Redox Signaling·J D Van BuulP L Hordijk
Jun 2, 2005·Cellular Signalling·Kendra D MartynUlla G Knaus
Sep 24, 2005·Cell·Sophie PattingreBeth Levine
Dec 7, 2005·The Journal of Cell Biology·Ru Feng WuLance S Terada
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Einav GrossDeborah Fass
Mar 24, 2006·Nature Methods·Vsevolod V BelousovSergey Lukyanov
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Brian OnkenEric C Chang
Aug 12, 2006·The Journal of Biological Chemistry·Tomohiro YorimitsuDaniel J Klionsky
Aug 23, 2006·The Journal of Cell Biology·Lance S Terada
Oct 13, 2006·Molecular and Cellular Biology·Maiko OgataKazunori Imaizumi
Jan 25, 2007·Molecular Cell·Maria Høyer-HansenMarja Jäättelä
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Oct 3, 2007·The Journal of Cell Biology·Zhenyi MaLance S Terada
Oct 18, 2007·The Journal of Biological Chemistry·Ru Feng WuLance S Terada
Jun 25, 2008·The Journal of Cell Biology·Kai ChenJohn F Keaney
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jyoti D MalhotraRandal J Kaufman
Apr 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ju HuangJohn H Brumell
Oct 12, 2010·Autophagy·Nicholas T KtistakisJoshua Long

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Citations

May 21, 2013·Antioxidants & Redox Signaling·Ralf P BrandesKatrin Schröder
Jan 5, 2014·Cell Communication and Signaling : CCS·Martin AugstenKarlheinz Friedrich
Apr 23, 2013·Antioxidants & Redox Signaling·Augusto C Montezano, Rhian M Touyz
Sep 18, 2013·Antioxidants & Redox Signaling·Yong-Han PaikDavid A Brenner
Nov 28, 2013·International Journal of Cell Biology·Thomas Ramming, Christian Appenzeller-Herzog
Mar 19, 2014·International Journal of Cell Biology·Mikael Molin, Ayse Banu Demir
Nov 12, 2013·Antioxidants & Redox Signaling·Zeynab NayerniaKarl-Heinz Krause
Jun 4, 2014·Antioxidants & Redox Signaling·Ahyoung LeeChangwon Kho
Jul 20, 2011·Nature Chemical Biology·Bryan C Dickinson, Christopher J Chang
May 23, 2012·AIDS Research and Therapy·M Scott Killian
Aug 21, 2019·Frontiers in Cardiovascular Medicine·Denise BurtenshawPaul A Cahill
Nov 11, 2016·Oxidative Medicine and Cellular Longevity·Alexander V IvanovMaria G Isaguliants
Feb 24, 2011·The Journal of Biological Chemistry·Ina TakacRalf P Brandes
May 24, 2012·Current Opinion in Lipidology·Xiangdong WuKevin Jon Williams
Oct 7, 2011·Cell Death & Disease·D R Gough, T G Cotter
Jun 22, 2012·Annals of Medicine·Augusto C Montezano, Rhian M Touyz
Feb 4, 2014·Oxidative Medicine and Cellular Longevity·Marianna GuidaAnto De Pol
Jan 31, 2015·Circulation Research·David I Brown, Kathy K Griendling
Dec 18, 2014·Clinical Science·Sebastiano SciarrettaJunichi Sadoshima
Mar 8, 2016·International Journal of Molecular Sciences·Hafiz Maher Ali ZeeshanHan-Jung Chae
Nov 20, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Ru Feng WuLance S Terada
Dec 1, 2017·Antioxidants & Redox Signaling·Stephen Jun Fei ChongShazib Pervaiz
Apr 21, 2018·International Journal of Molecular Sciences·Olga A SmirnovaAlexander V Ivanov
Feb 23, 2019·Viruses·Robert MeinekeHusni Elbahesh
May 5, 2012·Journal of Applied Physiology·Fangping ChenMitchell S Finkel
Sep 4, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Qiu Gen ZhouFan Fan Hou
Dec 8, 2011·Antioxidants & Redox Signaling·Taichi KakihanaRoberto Sitia
Jul 4, 2012·Antioxidants & Redox Signaling·Min ZhangAjay M Shah
Dec 7, 2013·Systems Biology in Reproductive Medicine·Petr ZolotukhinTatyana Shkurat
Jan 7, 2014·Antioxidants & Redox Signaling·Francisco R M LaurindoThalita B Abrahão
Dec 15, 2015·Nature Communications·Efrat DvashMenachem Rubinstein
Apr 28, 2018·Circulation Research·Steven J ForresterKathy K Griendling
Nov 14, 2018·The Journal of Biological Chemistry·Wataru R YamamotoCarmella Evans-Molina
Feb 28, 2020·Cytoskeleton·Nektarios Barabutis

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