Focal S100A4 protein expression is an independent predictor of development of metastatic disease in cystectomized bladder cancer patients

European Urology
Mads AgerbaekHans Von der Maase

Abstract

The prognosis of patients with apparently localized, operable, muscle-invasive bladder cancer depends to a large extent on the presence or absence of subclinical, microscopic distant metastases at the time of surgery. Expression of the S100A4 protein has been shown to correlate with the risk of metastasis in both animal tumour-model systems and clinical investigations in other tumour types. The purpose of the present study was to investigate the prognostic potential of S100A4 protein expression for predicting distant metastatic relapse in muscle-invasive bladder cancer. We analyzed 108 consecutive patients, treated for transitional cell bladder cancer with preoperative radiotherapy and cystectomy. Pretherapeutic biopsies of the bladder tumours were investigated for immunohistochemical expression of S100A4 protein and results, along with clinical and histopathological data, compared with the pattern of relapses over a 10+ yr follow-up period. Focal S100A4 protein expression emerged as the only significant independent predictor of distant metastatic relapse and distant metastasis-free survival in multivariate analysis. There is a potential role for this marker in denoting patients with high or low risk of distant relapse independ...Continue Reading

References

Apr 4, 1995·Biochimica Et Biophysica Acta·E TulchinskyE Lukanidin
Feb 13, 2002·The American Journal of Pathology·Diana LevettBarry R Davies
Feb 22, 2002·The Journal of Pathology·Barry R DaviesJ Kilian Mellon
Apr 17, 2002·International Journal of Oncology·Tetsu NakamuraYoshikazu Kuroda
May 11, 2002·Scandinavian Journal of Urology and Nephrology·A A El-AbbadyM Abdel-Rahman
May 5, 2005·Urologic Oncology·Brent K HollenbeckJohn T Wei

❮ Previous
Next ❯

Citations

Mar 7, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mikael SchneiderSøren P Sheikh
Jan 14, 2009·Cancer Immunology, Immunotherapy : CII·Valeska Hofmeister-MuellerJuergen C Becker
Nov 18, 2009·The Journal of Biological Chemistry·Thamir M IsmailRoger Barraclough
Sep 12, 2008·Carcinogenesis·Thamir M IsmailRoger Barraclough
May 31, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Navneeta BansalAbbas Ali Mahdi
Dec 8, 2015·Experimental and Therapeutic Medicine·Wen-Lei LiXing-Song Tian
Sep 23, 2008·International Journal of Cancer. Journal International Du Cancer·Olusola Y DokunWolfgang A Schulz
Jun 15, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I SalamaJ L Jones
Apr 22, 2006·European Urology·Henk G van der Poel
Oct 8, 2011·British Journal of Cancer·P P MunksgaardL Dyrskjøt
Oct 27, 2017·Oncotarget·Fei FeiShiwu Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.