Focal spinal arachnoiditis increases subarachnoid space pressure: a computational study

Clinical Biomechanics
Lynne E BilstonM A Stoodley

Abstract

Enlarging fluid filled cystic cavitations form within the spinal cord in up to 28% of spinal cord injured patients. These post-traumatic syrinxes can cause neurological deterioration and current treatment results are unsatisfactory. Localized scar tissue (arachnoiditis) within the subarachnoid space at the level of injury has been suggested to be involved in the pathogenesis of syrinx formation. This study tests the hypothesis that pressure pulses in the subarachnoid space are accentuated adjacent to regions of arachnoiditis, which may drive fluid into the spinal cord and contribute to syrinx formation. An axisymmetric, cylindrical computational fluid dynamics model was developed to represent the subarachnoid space under normal physiological conditions and in the presence of arachnoiditis. Cerebrospinal fluid flow into the model was estimated from magnetic resonance imaging flow studies. Arachnoiditis was modelled as a porous obstruction in the subarachnoid space. Peak fluid pressures were higher above the obstruction than in the absence of obstruction. The peak pressures were strongly dependent on the permeability of the obstruction. Elevations in subarachnoid space pressures due to arachnoiditis may facilitate fluid flow into...Continue Reading

References

Jan 1, 1996·Annals of Biomedical Engineering·L E Bilston, L E Thibault
Sep 10, 1998·Pediatric Neurosurgery·I G BloomfieldL E Bilston
Jul 9, 1999·Medical & Biological Engineering & Computing·E E JacobsonI H Johnston
Mar 30, 2001·Journal of Biomechanical Engineering·F LothN Alperin
Nov 27, 2002·Journal of Neurosurgery·Edward H Oldfield
Jul 11, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·A R Brodbelt, M A Stoodley
Sep 10, 2003·Computer Methods in Biomechanics and Biomedical Engineering·Lynne E BilstonMarcus A Stoodley
Oct 28, 2003·Journal of Neurotrauma·Andrew R BrodbeltNigel R Jones

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Citations

Dec 3, 2009·Journal of Neurosurgery. Spine·Sarah J HemleyMarcus A Stoodley
Mar 11, 2011·Journal of Neurosurgery. Spine·Michael G Fehlings, James W Austin
Jul 17, 2012·Journal of Neurosurgery. Spine·Jörg Klekamp
Jan 30, 2016·Journal of Neurosurgery. Spine·Johnny H Y WongMarcus A Stoodley
Apr 26, 2011·Neurological Research·Nicholas ShafferFrancis Loth
Oct 2, 2015·Asian Journal of Neurosurgery·Survendra Kumar Rajdeo Rai, Pooja Survendra Kumar Rai
Feb 7, 2012·Neurosurgery·Yongjie ZhangChristopher B Shields
Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Bryn A MartinNikolaos Stergiopulos
Nov 14, 2020·Fluids and Barriers of the CNS·Gabryel Conley NatividadBryn A Martin

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