Dec 9, 2014

Focus on GABA(A) receptor function. A comparative analysis of in vivo imaging studies in neuropsychiatric disorders

Nuklearmedizin. Nuclear Medicine
Susanne NikolausH-W Müller

Abstract

Impairment of GABA(A) receptor function is increasingly recognized to play a major role in the pathophysiology of neuropsychiatric diseases including anxiety disorder (AD), major depressive disorder (MDD) and schizophrenia (SZ). We conducted a PUBMED search, which provided a total of 23 in vivo investigations with PET and SPECT, in which GABA(A) receptor binding in patients with the primary diagnosis of AD (n = 14, 160 patients, 172 controls), MDD (n = 2, 24 patients, 28 controls) or SZ (n = 6, 77 patients, 90 controls) was compared to healthy individuals. A retrospective analysis revealed that AD, MDD and SZ differed as to both site(s) and extent(s) of GABAergic impairment. Additionally, it may be stated that, while the decline of GABA(A) receptor binding AD involved the whole mesolimbocortical system, in SZ it was confined to the frontal and temporal cortex. As GABA is known to inhibit dopamine and serotonin, GABAergic dysfunction may be associated with the disturbances of dopaminergic and serotonergic neurotransmission in neuropsychiatric disorders.

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Tomography, Emission-Computed, Single-Photon
Involutional Paraphrenia
Schizophrenia
Serotonin Measurement
Serotonin
Brain
Synaptic Transmission
Tomography, Emission-Computed
Dopamine Measurement

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