Focus on vitamin D and the adrenal gland

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Giovanna MuscogiuriKlaus Badenhoop

Abstract

The main role of vitamin D is to maintain calcium and phosphorus homeostasis, thus preserving bone health. However, recent evidences have demonstrated that vitamin D may also play a role in a variety of nonskeletal disorders such as endocrine diseases and in particular type 1 diabetes, type 2 diabetes, adrenal diseases, and the polycystic ovary syndrome. Despite controversial results on an association of low vitamin D levels with cortisol and aldosterone overproduction, encouraging in vitro findings have been reported on vitamin D effects in adrenocortical cancer cells. The focus of this review is the role of vitamin D in adrenal diseases and the results of vitamin D supplementation studies in patients. Although many studies support a beneficial role of vitamin D in adrenal disease, randomized controlled trials and mechanistic studies are required to provide more insight into the efficacy and safety of vitamin D as a therapeutic tool.

Citations

Feb 5, 2016·International Journal of Endocrinology·Catia PilonFrancesco Fallo
Oct 21, 2016·Reviews in Endocrine & Metabolic Disorders·Giacomo TirabassiGiancarlo Balercia
Jan 20, 2017·Reviews in Endocrine & Metabolic Disorders·Giovanna MuscogiuriFrancesco Orio
Jul 3, 2018·Minerva endocrinologica·Barbara AltieriAntongiulio Faggiano
Jan 8, 2020·European Journal of Clinical Nutrition·Barbara AltieriMichael F Holick
May 10, 2020·Anesthesia and Analgesia·Jonathan A PaulMatthew R Baldwin
Mar 3, 2020·The Journal of Sports Medicine and Physical Fitness·Mariagiovanna FilippellaAntongiulio Faggiano
Jan 31, 2020·Indian Journal of Psychological Medicine·Vikas MenonNaresh Nebhinani
Apr 16, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martin KaufmannGlenville Jones
May 16, 2021·Journal of Veterinary Internal Medicine·Andrea CorsiniFederico Fracassi

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