Focused Ultrasound and Other Lesioning Therapies in Movement Disorders

Current Neurology and Neuroscience Reports
Hannah Walters, Binit B Shah

Abstract

Lesioning therapies have been some of the earliest, most effective surgical treatments in movement disorders. This review summarizes recent studies, emerging modalities, and trends in lesioning procedures for movement disorders. Magnetic resonance-guided high-intensity focused ultrasound (MRgFUS) is the newest incisionless technology for lesioning procedures in movement disorders. It has recent FDA approval for thalamotomy in essential tremor and tremor-dominant Parkinson disease. There are current studies exploring subthalamotomy and pallidotomy in PD. Gamma knife is another incisionless modality that has been studied for decades and remains an effective treatment, albeit with less recent studies and more risks for adverse events, in movement disorders. Radiofrequency lesioning remains an efficacious treatment, particularly for unilateral pallidotomy in PD, but has fallen out of favor compared with other modalities, particularly MRgFUS. Lesioning therapies in movement disorders have shown efficacy in treating a variety of movement disorders. Enthusiasm for their use has waned with the advent of deep brain stimulation. The recent development of MRgFUS has recentered attention on lesioning therapy and its potential. Patient pref...Continue Reading

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Citations

Jan 28, 2020·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Abdullah Abuhaimed, Colin J Martin
Apr 30, 2020·Praxis·Markus F OertelLennart H Stieglitz
Feb 20, 2020·American Journal of Speech-language Pathology·Elizabeth Erickson-DiRenzoCasey H Halpern
Oct 20, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Francesco PradaFrederic Padilla
Jan 19, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Rachel Rinat BittonPejman Ghanouni
Oct 30, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vibhash D SharmaSvjetlana Miocinovic
Feb 11, 2021·Anesthesiology Clinics·Lane CrawfordLetha Mathews
Apr 4, 2021·Biosensors·Jiancheng Mo, Ronny Priefer
Aug 13, 2021·Journal of Neuro-oncology·Lior Lev-TovVivek P Buch

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