Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain

Journal of Controlled Release : Official Journal of the Controlled Release Society
Dezhuang YeHong Chen

Abstract

Focused ultrasound combined with microbubble-mediated intranasal delivery (FUSIN) is a new brain drug delivery technique. FUSIN utilizes the nasal route for direct nose-to-brain drug administration, thereby bypassing the blood-brain barrier (BBB) and minimizing systemic exposure. It also uses FUS-induced microbubble cavitation to enhance transport of intranasally (IN) administered agents to the FUS-targeted brain location. Previous studies have provided proof-of-concept data showing the feasibility of FUSIN to deliver dextran and the brain-derived neurotrophic factor to the caudate putamen of mouse brains. The objective of this study was to evaluate the biodistribution of IN administered gold nanoclusters (AuNCs) and assess the feasibility and short-term safety of FUSIN for the delivery of AuNCs to the brainstem. Three experiments were performed. First, the whole-body biodistribution of IN administered 64Cu-alloyed AuNCs (64Cu-AuNCs) was assessed using in vivo positron emission tomography/computed tomography (PET/CT) and verified with ex vivo gamma counting. Control mice were intravenously (IV) injected with the 64Cu-AuNCs. Second, 64Cu-AuNCs and Texas red-labeled AuNCs (TR-AuNCs) were used separately to evaluate FUSIN delivery...Continue Reading

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Citations

May 28, 2019·The Journal of Pharmacology and Experimental Therapeutics·Zian WangIjeoma F Uchegbu
Nov 21, 2020·Nanotoxicology·Vladimir V ChrishtopVladimir V Vinogradov
Jan 31, 2021·CNS Drugs·Manfred Hallschmid
May 20, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wejdan M ArifGert Luurtsema
Sep 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dezhuang YeHong Chen
Aug 19, 2021·Neuromolecular Medicine·Muna Aryal, Tyrone Porter
Aug 31, 2021·ACS Biomaterials Science & Engineering·Kahkashan BansalHimanshu Shekhar

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