Focused ultrasound facilitated thermo-chemotherapy for targeted retinoblastoma treatment: a modeling study

Experimental Eye Research
Shutao WangVesna Zderic

Abstract

Retinoblastoma is the most common type of intraocular tumors in children. Currently, with early detection and improved systemic chemo-adjuvant therapies, treatment paradigm has shifted from survival to globe salvation/vision preservation. The objective of our work has been to explore the possible application of focused ultrasound (FUS) for targeted drug delivery in the posterior pole retinoblastoma. Specifically, theoretical models were implemented to evaluate the feasibility of using FUS to generate localized hyperthermia in retinal tumor areas, for potential triggering the chemotherapeutic agent deployment from heat-sensitive drug carriers. In-vitro experiments were conducted in tissue-mimicking phantoms with embedded excised rabbit eyes to validate the reliability of the modeling results. After confirming the reliability of our model, various FUS transducer parameters were investigated to induce maximal hyperthermia coverage in the tumor, while sparing adjacent eye structures (e.g. the lens). The evaluated FUS parameters included operating frequency, total acoustic power, geometric dimensions, transducer f-number, standoff distance, as well as different pulsing scenarios. Our modeling results suggest that the most suitable u...Continue Reading

References

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Jul 27, 2011·The Journal of the Acoustical Society of America·Shutao WangVesna Zderic

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Citations

Mar 13, 2014·Ultrasound in Medicine & Biology·Arash RazaviCyril Lafon
Jan 5, 2016·Medical Engineering & Physics·Adam B NoverClark T Hung
Jan 15, 2013·Photochemistry and Photobiology·Stuart IbsenSadik Esener
Oct 3, 2015·Medical Physics·Marjan NabiliVesna Zderic
May 14, 2014·Advanced Drug Delivery Reviews·Alejandro Sosnik, Angel M Carcaboso
May 30, 2013·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Sean Quinlan-DavidsonJean Deschênes

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