Focused ultrasound modifications of neural circuit activity in a mammalian brain

Ultrasound in Medicine & Biology
M R BachtoldL R Price

Abstract

The application of focused, pulsed ultrasound was studied as a method of modifying the activity of a local neural circuit of the mammalian brain. An in vitro hippocampal preparation was used to facilitate delivery, dosimetry and assessment of mechanisms of ultrasound effects. Extracellular evoked potentials were recorded from cell and dendritic layers of the rat hippocampal dentate gyrus. Focused pulses of ultrasound with center frequency of 500 kHz and repetition rate of 200 kHz were studied and found both to enhance and to depress electrically evoked field potentials. The fiber volley and cell population potentials were depressed, whereas the dendritic potential was enhanced. Results suggest a simultaneous mechanical and thermal mechanism of ultrasound in modifying evoked field potentials of dentate local circuits.

Citations

Sep 5, 2002·Medical Hypotheses·S Bodovitz
Sep 3, 2011·Nature Protocols·Yusuf TufailWilliam J Tyler
Jun 22, 2011·The Journal of Head Trauma Rehabilitation·Asli Demirtas-TatlidedeAlvaro Pascual-Leone
Aug 31, 2011·Neuroreport·Seung-Schik YooShinsuk Park
Mar 8, 2011·BMC Neuroscience·Byoung-Kyong MinSeung-Schik Yoo
Oct 30, 2008·PloS One·William J TylerCassondra Majestic
Jul 6, 2012·Ultrasound in Medicine & Biology·Hyungmin KimSeung-Schik Yoo
Jul 23, 2011·Brain Stimulation·Alexander BystritskySeung-Schik Yoo
Dec 15, 2010·Medical Hypotheses·Tianhua YangDong Zhou
Nov 4, 2015·Ultrasound in Medicine & Biology·Wonhye LeeSeung-Schik Yoo
Aug 4, 2009·Ultrasound in Medicine & Biology·Vincent ColucciKullervo Hynynen
Apr 4, 2015·International Neurourology Journal·Jee Woong LeeYoonkey Nam
Jun 16, 2010·Neuron·Yusuf TufailWilliam J Tyler
Aug 26, 2011·Anesthesiology·Hariharan Shankar, Paul S Pagel
May 24, 2016·Journal of Therapeutic Ultrasound·Elisabetta Sassaroli, Natalia Vykhodtseva
Jan 28, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·William J Tyler
Apr 22, 2017·International Review of Psychiatry·Maria Fini, William J Tyler
Jun 25, 2019·Expert Review of Neurotherapeutics·Manish RanjanP David Adelson
May 7, 2016·Journal of Neural Engineering·Omer NaorShy Shoham
Jan 9, 2017·Biomedical Engineering Letters·Hongchae BaekHyungmin Kim
Nov 6, 2018·Current Behavioral Neuroscience Reports·Fabian MunozVincent P Ferrera
Feb 23, 2020·Scientific Reports·Priya S BalasubramanianAmit Lal
Apr 22, 2021·Medical & Biological Engineering & Computing·Huining GuoJie Chen
Sep 1, 2009·Environmental Toxicology and Pharmacology·Hua YuanXiang Mou

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