PMID: 7525342Aug 1, 1994Paper

Foetal airway motor tone in prenatal lung development of the pig

The European Respiratory Journal
M P SparrowH W Mitchell

Abstract

The terminal airways from embryonic lung in situ or as explants exhibit rhythmic spontaneous contractions. Our objective was to see whether narrowing responses of the airways occurred throughout the bronchial tree in the first trimester foetus and, if so, to characterize them. The bronchial tree was freed of vasculature and parenchyma from the lungs of 20-35 g pig foetuses (44-48 days gestation). The airway lumen was visualized directly with transmitted light, and narrowing was recorded in real time by video-imaging microscopy. From the main stem bronchi to the terminal regions of late generation branches (20-35 microns i.d.) strong bronchoconstrictor responses to micromolar concentrations of acetylcholine (ACh), histamine, substance P and K+ depolarizing solution were seen, whilst inhibition of narrowing with beta-adrenoceptor agonists was evidence of beta-receptors on the smooth muscle. Moreover, strong narrowing responses to electrical field stimulation, which were blocked by atropine, indicated that functional cholinergic nerves were present. A remarkable display of spontaneous narrowing in the airways of many of the bronchial tree preparations caused the movement of lung liquid to and fro. We speculate that the bronchomoto...Continue Reading

Citations

Oct 30, 2008·Pediatric Surgery International·Federica PederivaJuan A Tovar
Nov 12, 2010·Pediatric Surgery International·Toko ShinkaiPrem Puri
Oct 1, 2003·Respiratory Physiology & Neurobiology·Malcolm P Sparrow, Jasmine P Lamb
Mar 28, 1998·British Journal of Pharmacology·D R Connellan, H W Mitchell
Mar 1, 1997·Clinical and Experimental Pharmacology & Physiology·M P Sparrow, M Weichselbaum
Aug 28, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·William R HartmanChristina M Pabelick
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·M P SparrowP B McCray
Oct 28, 1999·American Journal of Respiratory Cell and Molecular Biology·M Weichselbaum, M P Sparrow
Jun 29, 2000·American Journal of Respiratory Cell and Molecular Biology·J C SchittnyM P Sparrow
Jun 29, 2000·American Journal of Respiratory Cell and Molecular Biology·K T Nakamura, P B McCray
Dec 4, 2004·American Journal of Respiratory Cell and Molecular Biology·Edwin C JesudasonPaul D Losty
May 14, 2005·American Journal of Respiratory Cell and Molecular Biology·Neil C FeatherstoneTheodor V Burdyga
Jun 2, 2007·American Journal of Respiratory Cell and Molecular Biology·Marta SantosJorge Correia-Pinto
Apr 17, 1998·Pediatric Research·V A SnetkovJ P Ward
May 29, 2002·Pediatric Research·Dharshini WignarajahRichard Harding
May 1, 2012·Revue des maladies respiratoires·A Hadchouel-DuvergéC Delacourt
Feb 2, 2017·Cell and Tissue Research·Johannes C Schittny
Feb 18, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jie PanErnest Cutz
May 18, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J TolletM P Sparrow
Apr 20, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Namjin Kim, Thiennu H Vu
May 7, 2020·Frontiers in Pediatrics·Michael B Anthracopoulos, Mark L Everard

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