FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice

Blood
Keiko MaedaHideoki Ogawa

Abstract

Cell-type-specific transcription of mouse high-affinity IgE receptor (FcepsilonRI) beta-chain is positively regulated by the transcription factor GATA-1. Although GATA-1 is expressed in erythroid cells, megakaryocytes, and mast cells, the expression of mouse FcepsilonRI beta-chain is restricted to mast cells. In the present study, we characterized the role of GATA-associated cofactor FOG-1 in the regulation of the FcepsilonRI beta-chain promoter. The expression levels of FOG-1, GATA-1, and beta-chain in each hematopoietic cell line were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. FOG-1 expression was higher in the beta-chain-negative hematopoietic progenitor cell line Ba/F3 than in the beta-chain-positive mast cell line PT18. By contrast, GATA-1 expression was similar when comparing the 2 cell lines. A transient reporter assay demonstrated that the beta-chain promoter functioned in PT18 but not in Ba/F3 and that the transcription activity of the beta-chain promoter in PT18 was markedly suppressed by overexpression of FOG-1. Although the activity of the beta-chain promoter, which was upregulated by coexpression of GATA-1, was significantly suppressed by coexpression of FOG-1 in the ...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·T BieberC de la Salle
May 1, 1992·The Journal of Experimental Medicine·B WangG Stingl
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y FujiwaraS H Orkin
May 15, 1998·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·H HarigaeM Yamamoto
Jun 8, 1999·Annual Review of Immunology·J P Kinet
Jun 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·N FossettR A Schulz
Sep 6, 2001·Blood·H KawabataH P Koeffler
Oct 25, 2001·Blood·M G MehaffeyJ G Drachman
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chiharu NishiyamaChisei Ra
Jun 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Aaron N ChangStuart H Orkin
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keiko MaedaChisei Ra
Apr 17, 2003·International Immunology·Yushiro AkizawaHideoki Ogawa
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masanari HasegawaHideoki Ogawa
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyoko TakahashiChisei Ra
May 28, 2005·The EMBO Journal·Patrick RodriguezJohn Strouboulis

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Citations

Feb 27, 2008·The Journal of Experimental Medicine·Alan B CantorStuart H Orkin
Oct 11, 2012·Development·Timothy M Chlon, John D Crispino
Sep 25, 2007·Leukemia & Lymphoma·Avichai Shimoni, Arnon Nagler
Sep 26, 2013·The Journal of Allergy and Clinical Immunology·Yuki NakamuraAtsuhito Nakao
Nov 25, 2011·The Journal of Allergy and Clinical Immunology·Nao KitamuraChiharu Nishiyama
Aug 4, 2009·Biochemical and Biophysical Research Communications·Tatsuo FukaiKo Okumura
Jun 29, 2007·The Journal of Investigative Dermatology·Atsushi TakagiHideoki Ogawa
Jan 13, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N ShimokawaH Ogawa
May 15, 2007·Immunological Reviews·Irit Carmi, Ehud Razin
Dec 13, 2006·Pediatric Blood & Cancer·Malcolm A SmithPeter J Houghton
Dec 17, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Takafumi NumataRyoji Tsuboi
Sep 30, 2015·Immunity, Inflammation and Disease·Tomonobu ItoRyoji Tsuboi
Jun 29, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Kentaro IshiyamaChiharu Nishiyama
Jul 25, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Yosuke BabaChiharu Nishiyama
Apr 19, 2017·Experimental Dermatology·Tarek HazzanMagda Babina
Feb 2, 2018·Scientific Reports·Yoshihito OdaChiharu Nishiyama
Jul 18, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuya YashiroChiharu Nishiyama
Feb 2, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazumi KasakuraChiharu Nishiyama
Apr 17, 2020·FEBS Open Bio·Takuya YashiroChiharu Nishiyama
Mar 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clifford M TakemotoMichael A McDevitt
Sep 14, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keiko MaedaKo Okumura
Apr 6, 2011·Leukemia & Lymphoma·Lauren S MaedaRanjana H Advani
May 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Su-Kang KongIl Yup Chung
Mar 19, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eisuke InageChiharu Nishiyama
Aug 25, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susumu YamazakiToshiaki Shimizu
Sep 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuya YashiroChiharu Nishiyama
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shunsuke KanadaChiharu Nishiyama
Mar 25, 2017·International Immunology·Takuya YashiroChiharu Nishiyama

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