Fogo selvagem: endemic pemphigus foliaceus.

Anais Brasileiros De Dermatologia
Günter Hans-FilhoGuilherme Canho Bittner

Abstract

Fogo selvagem or endemic pemphigus foliaceus is an autoimmune acantholytic anti-cadherin bullous disease that primarily affects seborrheic areas, which might disseminate. Brazil has the world's largest number of patients, mainly in the Central-West region, but the disease has also been reported in other South American countries. It affects young people and adults who have been exposed to rural areas, with occurrence of familial cases. Anti-desmoglein-1 autoantibodies are directed against desmosomal structures, with loss of adhesion of the upper layers of the epidermis, causing superficial blisters. The etiology is multifactorial and includes genetic, immune, and environmental factors, highlighting hematophagous insect bites; drug-related factors are occasionally involved. Flaccid blisters readily rupture to yield erosive-crusty lesions that sometimes resemble seborrheic dermatitis, actinic keratosis, and chronic cutaneous lupus erythematosus. The clinical presentation varies from localized to disseminated lesions. Clinical suspicion should be confirmed with histopathological and immunofluorescence tests, among others. The progression is usually chronic, and therapy varies according to clinical presentation, but generally requir...Continue Reading

References

Dec 11, 1976·British Medical Journal·R A MarsdenA G Mowat
Jan 1, 1989·The Journal of Investigative Dermatology·L A DiazC Lavrado
Apr 1, 1989·Journal of the American Academy of Dermatology·L A DiazC Lavrado
Dec 1, 1985·The Journal of Investigative Dermatology·J T RoscoeG J Anhalt
Jan 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·E H BeutnerO G Bier
Oct 1, 1983·Clinics in Dermatology·D F King, K Holubar
May 20, 1982·The New England Journal of Medicine·G J AnhaltL A Diaz
Jun 27, 1998·Clinics in Dermatology·S BrennerV Ruocco
Feb 18, 1999·The Journal of Clinical Investigation·M G MahoneyJ R Stanley
Dec 2, 2000·Journal of the American Academy of Dermatology·E Avalos-DíazL A Díaz
Jun 26, 2001·International Journal of Dermatology·E López-RoblesR Herrera-Esparza
Jan 22, 2003·The Journal of Investigative Dermatology·S J P WarrenL A Diaz
Sep 11, 2003·Clinical and Diagnostic Laboratory Immunology·Denise Bertulucci Rocha-RodriguesVirmondes Rodrigues Júnior
Feb 1, 1953·Medicine·W F LEVER
Oct 1, 1959·Archives of Dermatology·C E COUNTER
Nov 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·E H BEUTNER, R E JORDON
Feb 12, 2004·The Journal of Investigative Dermatology. Symposium Proceedings·Valeria AokiUNKNOWN Cooperative Group for Fogo Selvagem Research
Dec 8, 2004·Journal of the American Academy of Dermatology·Diya F Mutasim
Dec 22, 2004·The Journal of Investigative Dermatology·Luis A DiazUNKNOWN Cooperative Group on Fogo Selvagem Research
Nov 9, 2005·Experimental Dermatology·Cassian Sitaru, Detlef Zillikens
Jun 10, 2006·The Journal of Investigative Dermatology·Julio Hilario-VargasUNKNOWN Cooperative Group on Fogo Selvagem Research
Oct 26, 2007·The Journal of Investigative Dermatology·Luis A DiazUNKNOWN Cooperative Group on Fogo Selvagem Research
Apr 4, 2008·Histochemistry and Cell Biology·Jens Waschke
Jul 1, 2008·Journal of Oral Science·Manish Juneja
Aug 16, 2008·The Journal of Investigative Dermatology·Bahjat F QaqishUNKNOWN Cooperative Group on Fogo Selvagem Research
Nov 5, 2008·Journal of Dermatological Science·Masataka ArakawaTakashi Hashimoto
Jan 6, 2010·Archives of Dermatological Research·Enno Schmidt, Detlef Zillikens
May 25, 2011·Dermatologic Clinics·Kirk A JamesLuis A Diaz
May 25, 2011·Dermatologic Clinics·Deshan F Sebaratnam, Dédée F Murrell
Jun 18, 2011·Clinics in Dermatology·Sarah Brenner, Ilan Goldberg
Sep 24, 2011·Autoimmunity·Sergei A Grando
Dec 6, 2011·Clinics in Dermatology·Michael KasperkiewiczDetlef Zillikens
Dec 6, 2011·Clinics in Dermatology·Benjamin S DanielDédée F Murrell
Mar 13, 2012·Journal of Clinical Immunology·Rosangela Soares ChriguerMargaret de Castro
Jul 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ye QianLuis A Diaz
Jul 20, 2012·The Journal of Investigative Dermatology·Gustavo FloresLuis A Diaz
Jul 28, 2012·The British Journal of Dermatology·G van der WierG F H Diercks
Oct 17, 2012·The Journal of Investigative Dermatology·Giovanni Di ZenzoLuca Borradori
Jan 7, 2015·The Journal of Dermatology·Valeria AokiUNKNOWN Cooperative Group on Fogo Selvagem Research

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Citations

Jul 19, 2019·Journal of Exercise Rehabilitation·Rodolfo Pessato TimóteoCarlo José Freire Oliveira
Jul 9, 2020·Genetics and Molecular Biology·Maria Luiza Petzl-Erler
Mar 9, 2021·Journal of the American Academy of Dermatology·Carmen M MontagnonStanislav N Tolkachjov
Mar 9, 2021·Journal of the American Academy of Dermatology·Carmen M MontagnonJulia S Lehman
Jul 15, 2021·JAMA Dermatology·Rachel L FlintKristina Burke
Jul 29, 2021·Veterinary Pathology·Jeffrey B CurtissEmily P Mitchell
Aug 27, 2021·Frontiers in Medicine·Thomas Schmitt, Jens Waschke

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Methods Mentioned

BETA
immunoprecipitation
biopsies
ELISA
biopsy

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