Folate deficiency in the alcoholic--its relationship to clinical and haematological abnormalities, liver disease and folate stores.

British Journal of Haematology
A WuA J Levi

Abstract

Clinical and laboratory observations were made on 84 patients regularly taking more than 80 g of alcohol daily. Macrocytosis was present in 84.5%, but only 13% were anaemic. Twenty-seven of the 57 bone marrows sampled were abnormal, 20 showing megaloblastic changes, mostly mild in degree. Serum, red cell, and liver folate levels were reduced in 28%, 35% and 31% of patients respectively. Liver folate concentration showed good correlation with serum and red cell folates. The folate deficiency was more severe in those patients, more often female, who had inadequate diets or drank wine and spirits rather than beer. The amount of alcohol consumption and extent of liver damage did not affect folate status. The findings suggest that folate deficiency is common among alcoholics in this country. More frequently, however, patients had macrocytosis, sometimes with megaloblastosis, in the absence of folate deficiency emphasizing the direct toxic effect of alcohol on the developing erythroblast.

References

Apr 1, 1974·British Journal of Orthodontics·D C Picton
Jun 1, 1973·The Journal of Clinical Investigation·G Tisman, V Herbert
Jan 1, 1972·The American Journal of the Medical Sciences·E R EichnerR S Hillman
Aug 1, 1972·British Journal of Haematology·J M EnglandD A Waters
Nov 1, 1971·The British Journal of Addiction to Alcohol and Other Drugs·A J Gardner
Aug 1, 1970·Scottish Medical Journal·I R Williams, R H Girdwood
Feb 1, 1971·The American Journal of Medicine·E R Eichner, R S Hillman
Jan 1, 1969·British Journal of Haematology·I ChanarinV Wincour
Feb 12, 1966·British Medical Journal·I ChanarinM Moule
Dec 24, 1966·British Medical Journal·A H WatersJ G Rankin
Dec 2, 1967·British Medical Journal·M W Carney
Jan 1, 1963·The American Journal of Clinical Nutrition·V HERBERT
Nov 1, 1964·The Journal of Clinical Investigation·L W SULLIVAN, V HERBERT
Apr 1, 1965·The American Journal of Clinical Nutrition·C M LEEVYG R CHERRICK
Mar 1, 1955·The Journal of Clinical Investigation·J H JANDL

❮ Previous
Next ❯

Citations

Jul 1, 1996·Digestive Diseases and Sciences·D LambertJ P Nicolas
Feb 1, 1983·Irish Journal of Medical Science·E LawlorJ A Keogh
Jan 9, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B LarroqueG Crépin
Jun 1, 1992·The Journal of Pediatrics·J L MillsG G Rhoads
Aug 7, 2002·Alcohol·Charles H HalstedAngela M Devlin
Oct 24, 2001·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroD Machover
Mar 1, 1983·The Journal of Laryngology and Otology·N J MarksO H Shaheen
Oct 14, 2008·The Proceedings of the Nutrition Society·Simon Wheeler
Aug 23, 2012·European Journal of Clinical Nutrition·S VandevijvereR Moreno-Reyes
Nov 1, 1976·British Journal of Haematology·F LaneR S Hillman
Jul 1, 1979·British Journal of Haematology·I Chanarin
Jan 1, 2010·BMJ Case Reports·Viktoriya Clarke, Simon Weston-Smith
Jun 10, 1978·British Medical Journal
May 1, 1978·Journal of Clinical Pathology·R J Davidson, P J Hamilton
Jul 1, 1978·Journal of Clinical Pathology·E EschwegeD Schwartz
Jan 1, 1980·Journal of Clinical Pathology·D M ChalmersA J Levi
Feb 1, 1982·Journal of Clinical Pathology·M K Cook, M Madden
Dec 4, 2003·Journal of Clinical Pathology·M Galloway, L Rushworth
Sep 18, 2008·Journal of Nutritional Science and Vitaminology·Hee-Ah Kim, Hyeon-Sook Lim
Apr 12, 2014·BioMed Research International·Elena MantovaniMassimo Franchi
Aug 12, 1995·Lancet·I C Balfour, D W Lane
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Charles H HalstedS Jill James
Mar 2, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Christopher-John L FarrellMarkus Herrmann
Dec 15, 2004·Clinical and Laboratory Haematology·T LatifD J Adelstein
Feb 27, 2004·Addiction·Katherine M ConigraveJohn B Whitfield
Mar 1, 1980·British Journal of Addiction·M Davis
Jan 1, 1980·Clinical and Laboratory Haematology·T E Parry
Jul 1, 1978·Clinics in Endocrinology and Metabolism·R L Cumming, A Goldberg
May 5, 2017·Journal of Cellular Physiology·Seong Y HwangNam D Kim

❮ Previous
Next ❯

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