Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrence

International Journal of Cancer. Journal International Du Cancer
María Elena MartínezDavid S Alberts

Abstract

In 1996, the US Food and Drug Administration mandated the fortification of grain products with folic acid, a nutrient that has been associated with lower risk of colorectal neoplasia. We assessed the relation of plasma folate and homocysteine and colorectal adenoma recurrence separately in 2 studies: the first involved an intervention of a cereal supplement that contained folic acid, wheat bran fiber (WBF), and the second was conducted primarily during postfortification of the food supply using ursodeoxycholic acid (UDCA). Analyses were stratified for multivitamin use. Results show that plasma folate and homocysteine concentrations were associated with adenoma recurrence among nonusers of multivitamins only. Among nonmultivitamin users, the odds ratio [OR] (95% confidence interval [CI]) for those in the highest versus the lowest folate quartile was 0.65 (0.40-1.06) for the WBF study and 0.56 (0.31-1.02) for the UDCA; likewise, individuals in the highest versus the lowest quartile of homocysteine had higher odds of adenoma recurrence, in both the WBF (OR = 2.25; 95% CI = 1.38-3.66) and UDCA (OR = 1.93; 95% CI = 1.07-3.49) populations. Analyses comparing multivitamin users to different plasma folate concentrations among nonusers ...Continue Reading

References

Sep 30, 1992·Annals of the New York Academy of Sciences·C A LewisH E Sauberlich
Jan 1, 1995·Diseases of the Colon and Rectum·G A PaspatisD G Karamanolis
Nov 1, 1994·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M CravoC N Leitao
Jul 1, 1996·Food Additives and Contaminants·S G Capar, N J Yess
May 13, 1999·The New England Journal of Medicine·P F JacquesI H Rosenberg
Sep 18, 1999·Lancet·J M LawrenceM A Umekubo
Mar 17, 2000·The Journal of Nutrition·S W Choi, J B Mason
Apr 4, 2000·British Medical Bulletin·S J Duthie
Jan 3, 2001·Carcinogenesis·R K Le LeuG H McIntosh
Apr 2, 2004·Gastroenterology·M E MartínezD S Alberts
Jun 30, 2001·JAMA : the Journal of the American Medical Association·M A HoneinL Y Wong
Aug 7, 2002·The Journal of Nutrition·Sang-Woon Choi, Joel B Mason
Nov 11, 2003·The Journal of Nutrition·Young-In Kim
Mar 10, 2004·BMC Pregnancy and Childbirth·Rasiah VigneswaranJanet E Hiller
Mar 31, 2004·The American Journal of Clinical Nutrition·María Elena MartínezDavid S Alberts
Oct 23, 2004·International Journal of Cancer. Journal International Du Cancer·Miguel A SanjoaquinTimothy J Key
Nov 13, 2004·The Journal of Nutritional Biochemistry·Y I Kim
Apr 16, 2005·The Proceedings of the Nutrition Society·J J StrainH McNulty
May 5, 2005·Journal of the National Cancer Institute·Esther K WeiJing Ma
Jun 2, 2005·Journal of the National Cancer Institute·David S AlbertsUNKNOWN Phoenix and Tucson Gastroenterologist Networks

❮ Previous
Next ❯

Citations

Mar 7, 2008·Cancer Causes & Control : CCC·Gwen MurphyElaine Lanza
Feb 28, 2013·Nutrition and Cancer·Fang-Pei ChenYi-Chia Huang
May 23, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ma Luisa OjedaOlimpia Carreras
Aug 10, 2007·Journal of the National Cancer Institute·Regina G Ziegler, Unhee Lim
Apr 22, 2010·Journal of the National Cancer Institute·Christina C DahmSheila A Rodwell Bingham
Aug 19, 2007·Journal of Clinical Gastroenterology·Elizabeth T JacobsMaría Elena Martínez
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Julia SauerSang-Woon Choi
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jane C FigueiredoJohn A Baron
May 27, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gerd BobeAmanda J Cross
Sep 16, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·A Joan LevineJohn A Baron
Feb 25, 2010·World Journal of Gastroenterology : WJG·Wan DuJing-Yuan Fang
Jun 1, 2012·The American Journal of Clinical Nutrition·Ashley J VargasPatricia A Thompson
Feb 22, 2013·The American Journal of Clinical Nutrition·Joshua W MillerCornelia M Ulrich
Apr 14, 2012·Drug Metabolism Reviews·Jose J G MarinOscar Briz
Dec 2, 2015·Bone·Elizabeth A HiblerElizabeth T Jacobs
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·I T Johnson, E K Lund
Feb 13, 2013·Molecular Nutrition & Food Research·Jane C FigueiredoRobert W Haile
Dec 21, 2010·International Journal of Cancer. Journal International Du Cancer·Jane C FigueiredoJohn A Baron
Jul 1, 2014·International Journal of Cancer. Journal International Du Cancer·Anouar FanidiMattias Johansson
Oct 18, 2008·The Journal of Nutritional Biochemistry·Robert S ChapkinRichard H Finnell
Sep 18, 2015·Journal of the National Cancer Institute·Eunyoung ChoEdward L Giovannucci
Oct 22, 2004·Nutrition Journal·Michael S Donaldson
Apr 7, 2015·Progress in Biophysics and Molecular Biology·Kimberly R ShorterPaul B Vrana
Apr 4, 2017·Epidemiology·Duncan C Thomas
Nov 29, 2007·Current Opinion in Gastroenterology·Robert S Bresalier
Jan 15, 2009·Nature Reviews. Cancer·María Elena MartínezEdward Giovannucci
Oct 11, 2017·Nutrition Research and Practice·Yeong Mi ParkJung Eun Lee
Jan 30, 2015·World Journal of Gastroenterology : WJG·Ammar Hassanzadeh KeshteliKaren L Madsen
Jan 9, 2017·The Cochrane Database of Systematic Reviews·Yibo YaoEvelyne Chui
Jun 23, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stefan de VogelGeir Hoff
Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Melissa Y WeiEdward Giovannucci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Clinical Nutrition
Jung Eun LeeE Giovannucci
International Journal of Cancer. Journal International Du Cancer
Carlo La VecchiaSilvia Franceschi
© 2022 Meta ULC. All rights reserved