Folate gene polymorphisms MTR A2756G, MTRR A66G, and BHMT G742A and risk for coronary artery disease: a meta-analysis

Genetic Testing and Molecular Biomarkers
Prakruti R Singh, Smita S Lele

Abstract

Folate pathway gene polymorphisms may be a risk factor for coronary artery disease (CAD). However, studies of the association between these polymorphisms and CAD have reported conflicting results. Therefore, we performed a meta-analysis to better assess the association. To investigate the association between 3 major polymorphisms in genes encoding enzymes involved in remethylation of homocysteine to methionine--methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, and betaine homocysteine methyltransferase (BHMT) G742A--and CAD, with assessment of small-study bias and differences between studies. Case-control studies were identified by searching electronic literature databases for relevant reports published before February 2011. Data on genotype frequency were extracted, and 4 genetic models were applied. Heterogeneity was explored with stratification by ethnicity of the study sample. We found weak evidence of a recessive effect of the G allele in MTR A2756G (odds ratio, 1.61 [95% confidence interval, 0.98-2.66]; p=0.06). No effect of MTRR A66G and BHMT G742A in dominant, recessive, homozygous, and contrast allele genetic models was observed. Known common single-nucleotide polymorphisms in MTRR and BHMT g...Continue Reading

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Methods Mentioned

BETA
genotyping

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Comprehensive Meta Analysis

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