Folate, homocysteine and methionine loading in patients on carbamazepine

Acta Neurologica Scandinavica
T ApelandO Kristensen

Abstract

Some antiepileptic drugs (AEDs) are associated with low levels of serum (S-FA) and erythrocyte folate (E-FA) and high levels of plasma total homocysteine (p-tHcy). We have explored the concentrations of S-FA, E-FA and p-tHcy in patients on carbamazepine (CBZ). The methionine loading test was applied for better assessment of mildly impaired homocysteine metabolism. The study comprised 42 adult patients on CBZ and 42 matched healthy controls. Blood samples were drawn prior to and 6 h post methionine loading (6 h-PML) (0.1 g/kg body weight). The patients on CBZ had significantly lower concentrations of fasting S-FA and E-FA than the controls (P=0.0004, P=0.003, respectively). Fasting and 6 h-PML p-tHcy concentrations were significantly higher in the patients than in the controls (P=0.03 and P=0.0001, respectively). The methionine loading test identified additional patients with hyperhomocysteinemia undetected by fasting p-tHcy. CBZ therapy may be associated with low folate and high p-tHcy levels.

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Citations

Oct 24, 2001·Epilepsy Research·T ApelandR E Strandjord
Oct 26, 2002·Epilepsy Research·Terje ApelandRoald E Strandjord
Nov 3, 2004·Akusherstvo i ginekologii︠a︡·V StoĭkovaA Tsoncheva
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Sunil AsnaniVivian A Fonseca
Aug 26, 2009·Epilepsia·Scott Mintzer, Richard T Mattson
May 22, 2007·Epilepsy Research·Margitta T Kampman
Mar 20, 2009·Annals of Neurology·Scott MintzerMichael R Sperling
Jan 18, 2006·Seizure : the Journal of the British Epilepsy Association·Ufuk SenerMurat Topbas
Nov 9, 2016·Archives of Disease in Childhood·Saravanan ChandrasekaranPratibha Singhi
Aug 1, 2013·Journal of the American Heart Association·Elisabetta PatornoSebastian Schneeweiss
Jan 15, 2008·International Journal of Laboratory Hematology·K AslanB Güvenc
Feb 4, 2010·Current Opinion in Neurology·Scott Mintzer
Jan 9, 2017·European Journal of Drug Metabolism and Pharmacokinetics·Natasa DjordjevicJasmina R Milovanovic
Dec 1, 2018·Archives of Toxicology·M VidmarM Sollner Dolenc
Jul 15, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maryam SafahaniAli A Asadi-Pooya

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